Autophagy and cancer

Beth Levine

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Autophagy and cancer

机译：自噬与癌症

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Autophagy is the degradation of redundant or faulty cell components. It occurs as part of a cell's everyday activities and as a response to stressful stimuli, such as starvation. Connections with cellular life-and-death decisions and with cancer are now emerging.rnHow is autophagy induced?rnAutophagy occurs when cells need to 'self-cannibalize' or degrade their constituents. Underlying 'housekeeping' levels of autophagy probably occur in most normal cells to prevent the accumulation of protein aggregates and defective cellular substructures. Certain environmental cues (such as starvation, high temperature, low oxygen, hormonal stimulation) or intracellular stress (damaged organelles, accumulation of mutant proteins, microbial invasion) activate signalling pathways that increase autophagy.

机译：自噬是冗余或有故障的电池组件的退化。它是细胞日常活动的一部分，并且是对诸如饥饿之类的压力刺激的反应。与细胞生死决定和癌症的联系正在兴起。自噬是如何诱导的？当细胞需要“自噬”或降解其成分时，就会发生自噬。在大多数正常细胞中，潜在的自噬“内在”水平可能会发生，以防止蛋白质聚集体和有缺陷的细胞亚结构的积累。某些环境提示（例如饥饿，高温，低氧，激素刺激）或细胞内应激（细胞器受损，突变蛋白的积累，微生物入侵）激活了增加自噬的信号传导途径。

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《Nature》 |2007年第7137期|745-747|共3页
作者
Beth Levine;
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作者单位

Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9113, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Blocking autophagy enhances the pro-apoptotic effect of bufalin on human gastric cancer cells through endoplasmic reticulum stress Blocking autophagy enhances the pro-apoptotic effect of bufalin on human gastric cancer cells through endoplasmic reticulum stress Blocking autophagy enhances the pro-apoptotic effect of bufalin on human gastric cancer cells through endoplasmic reticulum stress [J] . Hongyan Zhao, Hongwei Li, Jie Pang, Biology Open . 2017,第10期

机译：阻断自噬通过内质网应激增强bufalin对人胃癌细胞的促凋亡作用阻断自噬通过内质网应激增强bufalin对人胃癌细胞的促凋亡作用胃癌细胞通过内质网应激
2. Role of autophagy in regulation of cancer cell death/apoptosis during anti-cancer therapy: focus on autophagy flux blockade [J] . Archives of pharmacal research . 2020,第5期

机译：自噬在抗癌治疗过程中癌细胞死亡/细胞凋亡调控的作用：专注于自噬通量阻滞
3. Colchicine induces autophagy and senescence in lung cancer cells at clinically admissible concentration: potential use of colchicine in combination with autophagy inhibitor in cancer therapy [J] . Bhattacharya Surela, Das Amlan, Datta Satabdi, Tumour biology : . 2016,第8期

机译：秋水仙碱可在临床上可接受的浓度下诱导肺癌细胞自噬和衰老：秋水仙碱与自噬抑制剂联合在癌症治疗中的潜在用途
4. Zero-valent iron based nanoparticles selectively inhibit cancerous cells through mitochondria-mediated autophagy [C] . Dar-Bin Shieh, Li-Xing Yang, Wei-Ting Lee, International Conference on Nanotechnology . 2017

机译：零价铁基纳米颗粒通过线粒体介导的自噬选择性抑制癌细胞
5. A Pharmacokinetic Investigation of Chloroquine Analogues in Cancer Autophagy Modulation [D] . Collins, Keagan P. 2020

机译：癌症自噬调制中氯喹类似物的药代动力学调查
6. Autophagy Defects Suggested by Low Levels of Autophagy Activator MAP1S and High Levels of Autophagy Inhibitor LRPPRC Predict Poor Prognosis of Prostate Cancer Patients [O] . Xianhan Jiang, Weide Zhong, Hai Huang, -1

机译：低水平的自噬激活剂MAP1S和高水平的自噬抑制剂LRPPRC提示自噬缺陷可预测前列腺癌患者的预后不良。
7. Autophagy Beyond Homeostasis: Does Autophagy Dysregulation Drive Colorectal Cancer? Comment on Shawn Gurwara et al; Altered Expression of Autophagy-related Genes in Human Colon Cancer [O] . Anand Singh 2018

机译：超越稳态外的自噬：是否自噬能量测定驱动结直肠癌？关于Shawn Gurwara等人的评论;改变了人结肠癌中自噬相关基因的表达

Autophagy and cancer

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