The complex language of chromatin regulation during transcription

Shelley L. Berger

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The complex language of chromatin regulation during transcription

机译：转录过程中染色质调控的复杂语言

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An important development in understanding the influence of chromatin on gene regulation has been the finding that DNA methylation and histone post-translational modifications lead to the recruitment of protein complexes that regulate transcription. Early interpretations of this phenomenon involved gene regulation reflecting predictive activating or repressing types of modification. However, further exploration reveals that transcription occurs against a backdrop of mixtures of complex modifications, which probably have several roles. Although such modifications were initially thought to be a simple code, a more likely model is of a sophisticated, nuanced chromatin 'language' in which different combinations of basic building blocks yield dynamic functional outcomes.

机译：理解染色质对基因调控的影响的一项重要进展是发现DNA甲基化和组蛋白翻译后修饰可导致募集调节转录的蛋白质复合物。这种现象的早期解释涉及基因调控，反映了预测性的激活或抑制类型的修饰。但是，进一步的探索表明，转录是在复杂修饰的混合物的背景下发生的，该修饰可能具有多种作用。尽管最初认为这种修改是简单的代码，但更可能的模型是复杂的细微染色质“语言”，其中基本构建块的不同组合产生动态的功能结果。

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来源
《Nature》 |2007年第7143期|p.407-412|共6页
作者
Shelley L. Berger;
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作者单位

The Wistar Institute, 3601 Spruce Street, Room 201, Philadelphia, Pennsylvania 19104, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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机译：PAF1复合物：在转录和染色质界面运行的核调节的梯度
2. Gene regulation at a distance: Higher-order chromatin folding and the coordinated control of gene transcription at the epidermal differentiation complex locus [J] . FessingM.Y. The Journal of investigative dermatology. . 2014,第9期

机译：远距离的基因调节：高阶染色质折叠和表皮分化复合物基因座上基因转录的协调控制
3. Complex mutual regulation of facilitates chromatin transcription (FACT) subunits on both mRNA and protein levels in human cells [J] . SafinaA., GarciaH., CommaneM., Cell cycle . 2013,第15期

机译：复杂的相互调控促进人类细胞mRNA和蛋白质水平上的染色质转录（FACT）亚基
4. Functional Proteomics Establishes the Interaction of SIRT7 with Chromatin Remodeling Complexes and Expands its Role in RNA Pol I Transcription. [C] . Yuan-Chin Tsai, Todd M. Greco, Apaporn Boonmee, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：功能性蛋白质组学建立了SIRT7与染色质重塑复合物的相互作用，并扩大其在RNA Pol I转录中的作用。
5. Roles of chromatin and Mediator complex in transcriptional regulation of the Saccharomyces cerevisiae CHA1 gene [D] . He, Qiye 2008

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6. Drosophila Zinc Finger Protein CG9890 Is Colocalized with Chromatin Modifying and Remodeling Complexes on Gene Promoters and Involved in Transcription Regulation [O] . N. A. Fursova, M. Y. Mazina, J. V. Nikolenko, 2020

机译：果蝇锌指蛋白CG9890与基因启动子上的染色质修饰和改造复合物分致铬化并参与转录调控
7. Chromatin architecture and transcriptional regulation at the Epidermal Differentiation Complex (EDC) locus. The role of epigenetic factors in modulating chromatin structure and tissue-specific gene expression at the murine EDC locus during epidermal differentiation. [O] . Yarker Joanne Lauren 2014

机译：表皮分化复合体（EDC）位点的染色质结构和转录调控。表观遗传因素在表皮分化过程中在小鼠EDC基因座上调节染色质结构和组织特异性基因表达的作用。

The complex language of chromatin regulation during transcription

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