Right timing for retina repair

Thomas A. Reh

首页> 外文期刊>Nature >Right timing for retina repair

【24h】

Right timing for retina repair

机译：视网膜修复的正确时机

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Transplants of photoreceptor cells offer hope for treating retinal disease. But getting the cells to make the right connections with the brain has been problematic. It seems the developmental stage of the cells may be the key. Each year many people lose their sight through disease of the retina. Millions are affected by macular degeneration and retinitis pigmentosa alone. In these diseases, the cone and rod photoreceptors — the cells that convert light into neural signals — degenerate. And once these cells are lost, they are not replaced in the mammalian retina. Treatments are being developed that may delay or prevent the loss of retinal neurons in these disorders. But for those who have already lost their sight, the possibility of retinal transplantation may be the best prospect for the restoration of vision through cell-replacement therapy. Despite many attempts, such transplants have yet to produce better vision in mammals because the transplanted cells do not wire up to the brain properly. In this issue, MacLaren et al. (page 203) show in mice that the trick may be to use cells at a particular stage in their development.

机译：感光细胞的移植为治疗视网膜疾病提供了希望。但是，让细胞与大脑建立正确的连接一直是个问题。看来细胞的发育阶段可能是关键。每年，许多人会因视网膜疾病而失去视力。数以百万计的人受黄斑变性和色素性视网膜炎的影响。在这些疾病中，视锥和视杆感光器（将光转换为神经信号的细胞）会退化。一旦这些细胞丢失，它们就不会在哺乳动物的视网膜中被替换。正在开发可以延迟或预防这些疾病中视网膜神经元丧失的治疗方法。但是对于那些已经失去视力的人来说，视网膜移植的可能性可能是通过细胞置换疗法恢复视力的最佳前景。尽管进行了许多尝试，但这种移植尚未在哺乳动物中产生更好的视力，因为移植的细胞无法正确地与大脑连接。在本期中，MacLaren等人。（第203页）显示了小鼠的诀窍可能是在其发育的特定阶段使用细胞。

著录项

来源
《Nature》 |2006年第7116期|p.156-157|共2页
作者
Thomas A. Reh;
展开▼
作者单位

展开▼
收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词

相似文献

外文文献
中文文献
专利

1. Developmental decline in DNA repair in neural retina cells of chick embryos: persistent deficiency of repair competence in a cell line derived from late [J] . P Karran, A Moscona, B Strauss Journal of cell biology . 1977,第1期

机译：鸡胚神经视网膜细胞中DNA修复的发育下降：晚期来源的细胞系中修复能力的持续缺陷
2. Timing Is Everything Commentary on an article by Brian Forsythe, MD, et al.: "The Timing of Injections Prior to Arthroscopic Rotator Cuff Repair Impacts the Risk of Surgical Site Infection" [J] . Hasan Samer S. The Journal of Bone and Joint Surgery. American Volume . 2019,第8期

机译：正时是Brian Forsythe，MD等，MD等的一切评论：“关节镜旋转器袖带修复前的注射时间影响外科遗址感染的风险”
3. Outcomes of Common Atrioventricular Valve Repair in Patients With Single-Ventricle Physiology　― Indication, Timing and Repair Techniques ― [J] . Fengpu He, Yiping Jiao, Kai Ma, Circulation journal . 2019,第3期

机译：单心室生理学患者共同的房室瓣膜修复结果 - 指示，时序和修复技术 -
4. Unsupervised features extraction from asynchronous silicon retina through Spike-Timing-Dependent Plasticity [C] . Bichler Olivier, Querlioz Damien, Thorpe Simon J., The 2011 International Joint Conference on Neural Networks . 2011

机译：通过峰值计时相关的可塑性从异步硅视网膜中提取无监督特征
5. Social and Cognitive Influences on the Timing of Other-initiations of Repair [D] . Mertens, Julia. 2019

机译：社会和认知对修复的其他启动时机的影响
6. Developmental decline in DNA repair in neural retina cells of chick embryos: persistent deficiency of repair competence in a cell line derived from late [O] . P Karran, A Moscona, B Strauss 1977

机译：鸡胚神经视网膜细胞中DNA修复的发育下降：晚期来源的细胞系中修复能力的持续缺陷
7. Developmental decline in DNA repair in neural retina cells of chick embryos: persistent deficiency of repair competence in a cell line derived from late [O] . Karran, P, Moscona, A, Strauss, B 1977

机译：鸡胚神经视网膜细胞中DNA修复的发育下降：晚期来源的细胞系中修复能力的持续缺陷
8. Neural Responses to Injury: Prevention, Protection, and Repair. Volume 7. Role of Growth Factors and Cell Signaling in the Response of Brain and Retina to Injury [R] . Bazan, N. G. 1997

机译：对损伤的神经反应：预防，保护和修复。第7卷。生长因子和细胞信号在脑和视网膜损伤反应中的作用

Right timing for retina repair

摘要

著录项

相似文献

相关主题

期刊订阅