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首页> 外文期刊>Nature >Protein delivery into eukaryotic cells by type III secretion machines
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Protein delivery into eukaryotic cells by type III secretion machines

机译：通过III型分泌机将蛋白质输送到真核细胞中

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摘要

Bacteria that have sustained long-standing close associations with eukaryotic hosts have evolved specific adaptations to survive and replicate in this environment. Perhaps one of the most remarkable of those adaptations is the type III secretion system (T3SS) - a bacterial organelle that has specifically evolved to deliver bacterial proteins into eukaryotic cells. Although originally identified in a handful of pathogenic bacteria, T3SSs are encoded by a large number of bacterial species that are symbiotic or pathogenic for humans, other animals including insects or nematodes, and plants. The study of these systems is leading to unique insights into not only organelle assembly and protein secretion but also mechanisms of symbiosis and pathogenesis.
机译：与真核宿主长期保持密切联系的细菌已经进化出特定的适应性，可以在这种环境下生存和复制。这些改造中最显着的变化之一可能是III型分泌系统（T3SS），它是一种细菌细胞器，专门进化为将细菌蛋白传递到真核细胞中。尽管T3SS最初是在少数致病细菌中鉴定出来的，但它们却由大量对人类，其他动物（包括昆虫或线虫和植物）具有共生或致病性的细菌物种编码。对这些系统的研究不仅对细胞器组装和蛋白质分泌，而且对共生和发病机理都有着独特的见解。

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