Essential role for collectrin in renal amino acid transport

Danilczyk U; Sarao R; Remy C; Benabbas C; Stange G; Richter A; Arya S; Pospisilik JA; Singer D; Camargo SMR

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Essential role for collectrin in renal amino acid transport

机译：Collectrin在肾脏氨基酸转运中的重要作用

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Angiotensin-converting enzyme 2 (ACE2) is a regulator of the renin angiotensin system involved in acute lung failure, cardiovascular functions and severe acute respiratory syndrome (SARS) infections in mammals(1-3). A gene encoding a homologue to ACE2, termed collectrin (Tmem27), has been identified in immediate proximity to the ace2 locus(4). The in vivo function of collectrin was unclear. Here we report that targeted disruption of collectrin in mice results in a severe defect in renal amino acid uptake owing to downregulation of apical amino acid transporters in the kidney. Collectrin associates with multiple apical transporters and defines a novel group of renal amino acid transporters. Expression of collectrin in Xenopus oocytes and Madin-Darby canine kidney (MDCK) cells enhances amino acid transport by the transporter B-0 AT1. These data identify collectrin as a key regulator of renal amino acid uptake.

机译：血管紧张素转换酶2（ACE2）是肾素血管紧张素系统的调节剂，参与哺乳动物的急性肺衰竭，心血管功能和严重急性呼吸综合征（SARS）感染（1-3）。已经在ace2基因座附近发现了一个编码ACE2同源基因的基因，称为collectrin（Tmem27）（4）。收集蛋白的体内功能尚不清楚。在这里我们报告说，由于肾中顶氨基酸转运蛋白的下调，小鼠中collectrin的靶向破坏导致肾脏氨基酸摄取的严重缺陷。 Collectrin与多个顶端转运蛋白缔合，并定义了一组新的肾脏氨基酸转运蛋白。蟾蜍卵母细胞和Madin-Darby犬肾（MDCK）细胞中collectrin的表达增强了转运蛋白B-0 AT1的氨基酸转运。这些数据确定collectrin是肾氨基酸摄取的关键调节剂。

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来源
《Nature》 |2006年第7122期|p. 1088-1091|共4页
作者
Danilczyk U; Sarao R; Remy C; Benabbas C; Stange G; Richter A; Arya S; Pospisilik JA; Singer D; Camargo SMR;
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作者单位

Austrian Acad Sci, IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria;

Univ Zurich, Inst Physiol, CH-8057 Zurich, Switzerland;

Univ Zurich, Ctr Integrat Human Physiol, CH-8057 Zurich, Switzerland;

Univ Vienna, Ctr Ecol, Dept chem Ecol & Ecosyst Res, A-1090 Vienna, Austria;

Hosp Sick Children, Toronto, ON M5G 1X8, Canada;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
ANGIOTENSIN-CONVERTING ENZYME-2; KIDNEY-CELLS; ACE2;

机译：血管紧张素转化酶2;肾脏细胞;ACE2;

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专利

1. Aminoaciduria and altered renal expression of luminal amino acid transporters in mice lacking novel gene collectrin. [J] . Malakauskas SM, Quan H, Fields TA, American Journal of Physiology . 2007,第2期

机译：缺乏新基因collectrin的小鼠中的氨基酸尿症和管腔氨基酸转运蛋白的肾脏表达改变。
2. Collectrin and ACE2 in renal and intestinal amino acid transport [J] . Singer Dustin, Camargo Simone M. R. Author Reprint Author, E-mail: simonemc@physiol.uzh.ch. Channels . 2011,第5期

机译：Collectrin和ACE2在肾脏和肠道氨基酸运输中的作用
3. Collectrin and ACE2 in renal and intestinal amino acid transport. [Review] [J] . Singer D, Camargo SM Channels . 2011,第5期

机译：Collectrin和ACE2在肾脏和肠道中的氨基酸转运。 [评论]
4. Role of excitatory amino acid transporter 1 in neonatal and adult rats neuronal damage induced by hypoxia-ischemia. [C] . Acta pharmacologica sinica . 2002

机译：兴奋性氨基酸转运蛋白1在缺氧缺血诱导的新生和成年大鼠神经元损伤中的作用。
5. Utilizing Genetic Techniques to Identify Amino Acids within the Putative Glycosyltransferase SypQ that Are Essential for Its Role in Biofilm Formation by Vibrio Fischeri [D] . Flaherty, Mary Kathryn. 2017

机译：利用遗传技术识别推定的糖基转移酶SypQ中的氨基酸，这对于费氏弧菌在生物膜形成中的作用至关重要
6. Molecular Basis for the Interaction of the Mammalian Amino Acid Transporters B0AT1 and B0AT3 with Their Ancillary Protein Collectrin [O] . Stephen J. Fairweather, Angelika Bröer, Nandhitha Subramanian, 2015

机译：哺乳动物氨基酸转运蛋白B0AT1和B0AT3与它们的辅助蛋白collectrin相互作用的分子基础。
7. Collectrin and ACE2 in renal and intestinal amino acid transport [O] . Singer, D, Camargo, S M R 2011

机译：Collectrin和ACE2在肾脏和肠道氨基酸运输中的作用

Essential role for collectrin in renal amino acid transport

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