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An obesity-associated gut microbiome with increased capacity for energy harvest

机译：肥胖相关的肠道微生物组，能量吸收能力增强

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The worldwide obesity epidemic is stimulating efforts to identify host and environmental factors that affect energy balance. Comparisons of the distal gut microbiota of genetically obese mice and their lean littermates, as well as those of obese and lean human volunteers have revealed that obesity is associated with changes in the relative abundance of the two dominant bacterial divisions, the Bacteroidetes and the Firmicutes. Here we demonstrate through metagenomic and biochemical analyses that these changes affect the metabolic potential of the mouse gut microbiota. Our results indicate that the obese microbiome has an increased capacity to harvest energy from the diet. Furthermore, this trait is transmissible: colonization of germ-free mice with an `obese microbiota' results in a significantly greater increase in total body fat than colonization with a 'lean microbiota'. These results identify the gut microbiota as an additional contributing factor to the pathophysiology of obesity.
机译：全球肥胖流行病正在刺激人们努力找出影响能量平衡的宿主和环境因素。对遗传性肥胖小鼠及其瘦肉同窝仔以及肥胖和瘦人志愿者的远端肠道菌群的比较显示，肥胖与两个主要细菌区（拟杆菌属和硬毛菌属）的相对丰度的变化有关。在这里，我们通过宏基因组学和生化分析证明，这些变化会影响小鼠肠道菌群的代谢潜能。我们的结果表明，肥胖的微生物组从饮食中获取能量的能力增强。此外，这种特性是可以传播的：用“肥胖微生物群”定植在无菌小鼠中会比“瘦微生物群”定植在总体内脂肪增加上明显更大。这些结果确定了肠道微生物群是肥胖症病理生理学的另一个促成因素。

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