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Design of effective immunotherapy for human autoimmunity

机译:用于人体自身免疫的有效免疫疗法设计

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A better understanding of the molecules involved in immune responses has identified many potential targets for the treatment of autoimmune diseases. But although successful therapies have been found for immune disorders in animal studies, few have passed the much harder test of treating human diseases. So far, non-antigen-specific approaches, such as the blocking of tumour-necrosis factor, are achieving some success but the same is not true for antigen-specific approaches. Future therapies will probably include both non-antigen-specific strategies that target cytokines ( cell - cell signalling molecules) or block the molecules that stimulate immune responses, and antigen-specific therapies that induce tolerance to self antigens.
机译:对参与免疫反应的分子的更好理解已经确定了许多治疗自身免疫性疾病的潜在靶标。但是,尽管在动物研究中发现了成功的免疫紊乱疗法,但很少有人通过更艰巨的人类疾病测试。到目前为止,非抗原特异性方法,例如阻断肿瘤坏死因子,已经取得了一些成功,但对于抗原特异性方法却并非如此。未来的疗法可能包括靶向细胞因子(细胞信号分子)或阻断刺激免疫反应的分子的非抗原特异性策略,以及诱导自身抗原耐受的抗原特异性疗法。

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