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Paths to understanding the genetic basis of autoimmune disease

机译:了解自身免疫性疾病遗传基础的途径

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摘要

Some people inherit an unfortunate combination of genetic sequences, such that exposure to an external trigger causes their immune response to turn on their own tissues. Although mutations in a single gene can cause autoimmunity, most autoimmune diseases are associated with several sequence variants. Marked advances in genetic resources and tools are now making it possible to identify the sequence variants that contribute to autoimmune diseases - promising a better understanding of how we normally remain tolerant of our own tissue components, and how this goes wrong in autoimmune disease.
机译:有些人继承了不幸的遗传序列组合,因此暴露于外部触发条件会导致他们的免疫反应打开自己的组织。尽管单个基因中的突变可引起自身免疫,但大多数自身免疫性疾病都与几种序列变异有关。遗传资源和工具的显着进步现在使人们有可能鉴定出导致自身免疫性疾病的序列变体-有望更好地了解我们通常如何耐受自己的组织成分,以及自身免疫性疾病如何出错。

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