Mutations in a signalling pathway

D. Williams Parsons; Tian-Li Wang; Yardena Samuels; Alberto Bardelli; Jordan M. Cummins; Laura DeLong; Natalie Silliman; Janine Ptak; Steve Szabo; James K. V. Willson; Sanford Markowitz; Kenneth W. Kinzler; Bert Vogelstein

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Mutations in a signalling pathway

机译：信号通路中的突变

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Protein kinases are enzymes that are impor-tant for controlling cellular growth and invasion, and their malfunction is implicated in the development of some tumours. We analysed human colorectal cancers for genetic mutations in 340 serine/threonine kinases and found mutations in eight genes, including in three members of the phosphatidylinositol-3-OH kinase (PI(3)K) pathway. The discovery of this mutational activation of a key cell-signalling pathway may provide new targets for therapeutic intervention.

机译：蛋白激酶是控制细胞生长和侵袭的重要酶，其功能紊乱与某些肿瘤的发生有关。我们分析了人类大肠癌中340个丝氨酸/苏氨酸激酶的基因突变，并发现了八个基因的突变，包括磷脂酰肌醇-3-OH激酶（PI（3）K）通路的三个成员。关键细胞信号通路的这种突变激活的发现可能为治疗干预提供新的靶标。

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《Nature》 |2005年第7052期|p.792|共1页
作者
D. Williams Parsons; Tian-Li Wang; Yardena Samuels; Alberto Bardelli; Jordan M. Cummins; Laura DeLong; Natalie Silliman; Janine Ptak; Steve Szabo; James K. V. Willson; Sanford Markowitz; Kenneth W. Kinzler; Bert Vogelstein;
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The Sidney Kimmel Comprehensive Cancer Center and The Howard Hughes Medical Institute, The Johns Hopkins University Medical Institutions, Baltimore, Maryland 21231, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Differential gene expression signatures between colorectal cancers with and without KRAS mutations: crosstalk between the KRAS pathway and other signalling pathways. [J] . Watanabe T, Kobunai T, Yamamoto Y, European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2011,第13期

机译：具有和不具有KRAS突变的大肠癌之间的差异基因表达特征：KRAS通路与其他信号通路之间的串扰。
2. Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma. [J] . Marks JL, Gong Y, Chitale D, Cancer research: The official organ of the American Association for Cancer Research, Inc . 2008,第14期

机译：通过对表皮生长因子受体信号转导通路基因在肺腺癌中的突变分析鉴定出新的MEK1突变。
3. Signal-Oriented Pathway Analyses Reveal a Signaling Complex as a Synthetic Lethal Target for p53 Mutations [J] . Lu Songjian, Cai Chunhui, Yan Gonghong, Cancer research: The official organ of the American Association for Cancer Research, Inc . 2016,第23期

机译：面向信号的途径分析揭示了信号复合物作为p53突变的合成致死目标。
4. A novel mutation of the PTCH1 gene activates the Shh/Gli signaling pathway in a Chinese family with nevoid basal cell carcinoma syndrome [C] . Tingting Zhang, Mingjie Chen, Yan Lü, Academic Committee Conference of Shanghai key lab of stomatology . 2011

机译：PTCH1基因的新型突变激活了中国患有避免基底细胞癌综合征的中国家庭的Shh / Gli信号通路
5. The role of mutational activation of RAS and PI3K signaling pathways in human tumors: Biologic and therapeutic implications. [D] . Halilovic, Ensar. 2009

机译：RAS和PI3K信号通路突变激活在人类肿瘤中的作用：生物学和治疗意义。
6. (Pro)renin receptor promotes colorectal cancer through the Wnt/beta-catenin signalling pathway despite constitutive pathway component mutations [O] . Juan Wang, Yuki Shibayama, Anqi Zhang, 2019

机译：（Pro）肾素受体尽管存在组成性途径成分突变但仍通过Wnt /β-catenin信号传导途径促进结直肠癌
7. (Pro)renin receptor promotes colorectal cancer through the Wnt/beta-catenin signalling pathway despite constitutive pathway component mutations [O] . Juan Wang, Yuki Shibayama, Anqi Zhang, 2018

机译：（Pro）肾素受体通过Wnt /β-catenin信号传导途径促进结肠直肠癌，尽管是组成型途径分量突变

Mutations in a signalling pathway

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