Prospects for a vaccine against the hepatitis C virus

Houghton M; Abrignani S

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Prospects for a vaccine against the hepatitis C virus

机译：丙型肝炎病毒疫苗的前景

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The recent discovery of natural immunity to the hepatitis C virus and vaccine efficacy in the chimpanzee challenge model has allowed optimism about the development of at least a partly effective vaccine against this heterogeneous pathogen that is responsible for much of the chronic liver disease around the world. The immune systems of some infected individuals can spontaneously clear the virus, whereas other people need treatment with antivirals that work partly by stimulating humoral and cellular immune responses. Therefore, therapeutic vaccine strategies are also being pursued to improve treatment outcome.

机译：最近发现的针对黑猩猩攻击模型的丙型肝炎病毒天然免疫力和疫苗功效，使人们对针对这种异质病原体的至少部分有效疫苗的开发抱有乐观态度，而这种病原体是全世界许多慢性肝病的病因。一些受感染个体的免疫系统可以自发清除病毒，而其他人则需要使用抗病毒药物进行治疗，这些药物可以通过刺激体液和细胞免疫反应来部分起作用。因此，也正在寻求治疗性疫苗策略以改善治疗效果。

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来源
《Nature》 |2005年第7053期|p. 961-966|共6页
作者
Houghton M; Abrignani S;
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作者单位

Chiron Corp, Emeryville, CA 94608 USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
CELLULAR IMMUNE-RESPONSES; CD8(+) T-CELLS; ENVELOPE PROTEIN; VIRAL CLEARANCE; NEUTRALIZING ANTIBODY; PROTECTIVE IMMUNITY; HELPER-CELLS; IN-VITRO; INFECTION; CHIMPANZEES;

机译：细胞免疫反应;CD8（+）T细胞;包膜蛋白;病毒清除;中和抗体;保护性免疫;肝细胞;体外;感染;黑猩猩;

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6. Hepatitis C Virus Vaccine: Challenges and Prospects [O] . Joshua D. Duncan, Richard A. Urbanowicz, Alexander W. Tarr, 2020

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Prospects for a vaccine against the hepatitis C virus

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