Hypothalamic regulation of sleep and circadian rhythms

Clifford B. Saper; Thomas E. Scammell; Jun Lu

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Hypothalamic regulation of sleep and circadian rhythms

机译：下丘脑调节睡眠和昼夜节律

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A series of findings over the past decade has begun to identify the brain circuitry and neurotransmitters that regulate our daily cycles of sleep and wakefulness. The latter depends on a network of cell groups that activate the thalamus and the cerebral cortex. A key switch in the hypothalamus shuts off this arousal system during sleep. Other hypothalamic neurons stabilize the switch, and their absence results in inappropriate switching of behavioural states, such as occurs in narcolepsy. These findings explain how various drugs affect sleep and wakefulness, and provide the basis for a wide range of environmental influences to shape wake-sleep cycles into the optimal pattern for survival.

机译：在过去的十年中，一系列发现已经开始识别调节我们日常睡眠和清醒周期的大脑电路和神经递质。后者取决于激活丘脑和大脑皮层的细胞群网络。下丘脑的钥匙开关会在睡眠期间关闭该唤醒系统。其他下丘脑神经元稳定开关，并且它们的缺失导致行为状态的不适当开关，例如发作性睡病。这些发现解释了各种药物如何影响睡眠和清醒，并为各种环境影响提供了基础，这些影响将唤醒-睡眠周期塑造为最佳生存模式。

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来源
《Nature》 |2005年第7063期|p.1257-1263|共7页
作者
Clifford B. Saper; Thomas E. Scammell; Jun Lu;
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作者单位

Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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Hypothalamic regulation of sleep and circadian rhythms

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