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RNA finds a simpler way

机译:RNA找到更简单的方法

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摘要

Is there no end to the versatility of RNA? The latest feat to be revealed is RNA's ability to switch off genes through a neatly straightforward mechanism. So it isn't only proteins that can repress gene activity. Organisms profit from synthesizing only those enzymes whose products are in demand. After all, if there's plenty of an amino acid around, why should a cell waste energy making the enzymes that are needed to generate it from precursors? A standard textbook mechanism by which this is achieved is repression. Repressor proteins sense when there is a build-up of a certain product, bind to the gene that encodes the enzyme that generates this product, and thereby inhibit the transcription of more messenger RNA (mRNA; Fig. 1a). On page 281 of this issue, Winkler et al. describe a bacterial gene-regulation system with a twist. The repressor is not a protein, but instead is a switchable (on-off) self-cleavage element within the mRNA itself.
机译:RNA的多功能性永无止境吗?最新发现的壮举是RNA通过简单明了的机制关闭基因的能力。因此,不仅蛋白质可以抑制基因活性。生物仅从合成需要其产品的酶中获利。毕竟,如果周围有很多氨基酸,为什么细胞要浪费能量来制造从前体生成氨基酸所需的酶?实现这一目标的标准教科书机制是压制。阻遏蛋白检测某种产物的积累,与编码产生这种产物的酶的基因结合,从而抑制更多信使RNA的转录(mRNA;图1a)。在本期杂志的第281页上,Winkler等人。描述一种带有扭曲的细菌基因调控系统。阻遏物不是蛋白质,而是mRNA本身内的可切换(开-关)自切割元件。

著录项

  • 来源
    《Nature》 |2004年第6980期|p.263-264|共2页
  • 作者

    Thomas R. Cech;

  • 作者单位

    Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, Maryland 20815;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 自然科学总论;
  • 关键词

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