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Tightrope act

机译:钢丝行为

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摘要

A component of the 'tip link' that conveys tension to mechanically sensitive ion channels in the inner ear has been identified. The finding raises new questions about elastic elements in our hearing apparatus. A snatch of music from far away or a slight turn of the head to find its source generates mechanical stimuli that are detected by hair cells of the inner ear. A bundle of finger-like stereocilia rises from the upper surface of each hair cell; stimuli that deflect these stereocilia by just a few nanometres can be reliably perceived. Biologists have a detailed understanding of the morphology and biophysical properties of the mechanically sensitive apparatus at the tips of stereocilia, but not of the protein constituents of this apparatus. In this issue, however, Nicolson and colleagues and Mueller and co-workers describe how they identified a major constituent of the tip link ― an extracellular filament that is stretched like a tightrope between the tops of adjacent stereocilia.
机译:已经确定了将尖端张力传递到内耳中机械敏感离子通道的“尖端连接”组件。这一发现提出了有关我们听力设备中弹性元件的新问题。从远处捕捉音乐或轻轻转动头部以寻找其来源会产生机械刺激,这些刺激会被内耳的毛细胞检测到。一束手指状的立体纤毛从每个毛细胞的上表面升起。可以可靠地感知到使这些纤毛纤毛偏斜几纳米的刺激。生物学家对机械敏感装置的形态和生物物理特性有很深的了解,即纤毛虫的尖端,但对该装置的蛋白质成分没有了解。但是,在本期杂志中,Nicolson和他的同事以及Mueller和同事描述了他们如何确定尖端连接的主要组成部分-一种细胞外细丝,像相邻绳索上的纤毛之间的绳索一样伸展。

著录项

  • 来源
    《Nature》 |2004年第6986期|p.901-903|共3页
  • 作者单位

    Howard Hughes Medical Institute and the Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 自然科学总论;
  • 关键词

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