Predicting disease using genomics

John Bell

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Predicting disease using genomics

机译：使用基因组学预测疾病

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Information from the human genome sequence will eventually alter many aspects of clinical practice. It will increase through our understanding of disease mechanisms, and guide the development of new drugs and therapeutic procedures. In the short term, however, knowledge of the genome will have a profound clinical impact on the diagnostic capability of clinical genetics laboratories. Molecular phenotyping using genetic and genomic information will allow early and more accurate prediction and diagnosis of disease and of disease progression. Medicine will become oriented towards disease prevention rather than efforts to cure people at late stages of illness.

机译：来自人类基因组序列的信息最终将改变临床实践的许多方面。通过我们对疾病机理的了解，它将增加，并指导新药和治疗程序的开发。但是，从短期来看，基因组的知识将对临床遗传学实验室的诊断能力产生深远的临床影响。利用遗传和基因组信息进行分子表型分析，将可以更早，更准确地预测和诊断疾病以及疾病的进展。医学将以预防疾病为中心，而不是在疾病晚期阶段治愈人们。

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来源
《Nature》 |2004年第6990期|p.453-456|共4页
作者
John Bell;
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作者单位

University of Oxford, Academic Centre, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. RICHARD M. SIMON . Genomic Clinical Trials and Predictive Medicine . Cambridge : Cambridge University Press . RICHARD M. SIMON RICHARD M. SIMON . Genomic Clinical Trials and Predictive Medicine Genomic Clinical Trials and Predictive Medicine . Cambridge Cambridge : Cambridge University Press Cambridge University Press . [J] . Matsui Shigeyuki Biometrics: Journal of the Biometric Society : An International Society Devoted to the Mathematical and Statistical Aspects of Biology . 2018,第2期

机译：Richard M. Simon。基因组临床试验和预测医学。剑桥：剑桥大学出版社。 Richard M. Simon Richard M. Simon。基因组临床试验及预测医学基因组临床试验及预测医学。剑桥剑桥：剑桥大学新闻出版社剑桥大学出版社。
2. The impact of genotype frequencies on the clinical validity of genomic profiling for predicting common chronic diseases. [J] . Janssens AC, Moonesinghe R, Yang Q, Genetics in medicine . 2007,第8期

机译：基因型频率对预测常见慢性疾病的基因组分布图临床有效性的影响。
3. Novel Genomic Biomarker Panel Predictive of Aggressive Disease in African American Men with Prostate Cancer [J] . Echevarria M., Awasthi S., Cheng C. H., International Journal of Radiation Oncology, Biology, Physics . 2018,第3Suppla期

机译：新型基因组生物标志物小组预测非洲裔美国男子前列腺癌的侵袭性疾病
4. Biostatistics Meets Bioinformatics in Integrating Information from Highdimensional Heterogeneous Genomic Data: Two Examples from Rare Genetic Diseases and Infectious Diseases [C] . Clelia Di Serio, Danilo Pellin, Alessandro Ambrosi, International meeting on computational intelligence methods for bioinformatics and biostatistics . 2012

机译：生物统计学在整合来自高维异构基因组数据的信息方面遇到了生物信息学：来自罕见遗传病和传染病的两个例子
5. Chromosomal Scale Length Variations as a Genetic Risk Score for Predicting Complex Human Diseases in Large Scale Genomic Datasets [D] . Toh, Christopher En-Li. 2021

机译：作为预测大规模基因组数据集中复杂人类疾病的遗传风险分数作为遗传风险分数的染色体刻度
6. Integrative systems of genomic risk markers for cancer and other diseases: future of predictive medicine [O] . Arseniy E Yuzhalin, Anton G Kutikhin 2012

机译：癌症和其他疾病的基因组风险标志物整合系统：预测医学的未来
7. Integrative systems of genomic risk markers for cancer and other diseases: future of predictive medicine [O] . Yuzhalin, Arseniy E, Kutikhin, Anton G 2012

机译：癌症和其他疾病的基因组风险标志物整合系统：预测医学的未来

Predicting disease using genomics

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