• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature >Mechanoelectrical transduction of adult outer hair cells studied in a gerbil hemicochlea
【24h】

Mechanoelectrical transduction of adult outer hair cells studied in a gerbil hemicochlea

机译：在沙鼠的半毛发中研究成年外毛细胞的机电转导

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Sensory receptor cells of the mammalian cochlea are morphologically and functionally dichotomized. Inner hair cells transmit auditory information to the brain, whereas outer hair cells (OHC) amplify the mechanical signal, which is then transduced by inner hair cells(1). Amplification by OHCs is probably mediated by their somatic motility(2,3) in a mechanical feedback process. OHC motility in vivo is thought to be driven by the cell's receptor potential. The first steps towards the generation of the receptor potential are the deflection of the stereociliary bundle(4), and the subsequent flow of transducer current through the mechanosensitive transducer channels located at their tips(5). Quantitative relations between transducer currents and basilar membrane displacements are lacking, as well as their variation along the cochlear length. To address this, we simultaneously recorded OHC transducer currents (or receptor potentials) and basilar membrane motion in an excised and bisected cochlea, the hemicochlea(6). This preparation permits recordings from adult OHCs at various cochlear locations while the basilar membrane is mechanically stimulated. Furthermore, the stereocilia are deflected by the same means of stimulation as in vivo. Here we show that asymmetrical transducer currents and receptor potentials are significantly larger than previously thought, they possess a highly restricted dynamic range and strongly depend on cochlear location.
机译：哺乳动物耳蜗的感觉受体细胞在形态和功能上被二分。内毛细胞将听觉信息传递到大脑，而外毛细胞（OHC）放大机械信号，然后由内毛细胞转导（1）。 OHC的放大可能是由它们在机械反馈过程中的体细胞运动性介导的（2,3）。体内OHC运动被认为是由细胞的受体电位驱动的。产生受体电位的第一步是立体睫状束的偏转（4），以及随后的换能器电流流经位于其尖端的机械敏感换能器通道（5）。缺少换能器电流和基底膜位移之间的定量关系，以及它们沿耳蜗长度的变化。为了解决这个问题，我们同时记录了OHC换能器电流（或受体电势）和经切除并一分为二的耳蜗半披耳（6）的基底膜运动。这种准备工作可以在机械刺激基底膜的同时，在各个耳蜗位置记录成年OHC的记录。此外，通过与体内相同的刺激手段使立体纤毛偏转。在这里，我们显示非对称换能器电流和受体电势比以前认为的要大得多，它们具有高度受限的动态范围，并且强烈依赖于耳蜗的位置。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号