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首页> 外文期刊>Nature >Restricted growth of Schwann cells lacking Cajal bands slows conduction in myelinated nerves
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Restricted growth of Schwann cells lacking Cajal bands slows conduction in myelinated nerves

机译：缺乏Cajal带的雪旺细胞的生长受限会减慢有髓神经的传导

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Nerve impulses are propagated at nodes of Ranvier in the myelinated nerves of vertebrates. Internodal distances have been proposed to affect the velocity of nerve impulse conduction(1); however, direct evidence is lacking, and the cellular mechanisms that might regulate the length of the myelinated segments are unknown. Ramon y Cajal described longitudinal and transverse bands of cytoplasm or trabeculae in internodal Schwann cells and suggested that they had a nutritive function(2). Here we show that internodal growth in wild-type nerves is precisely matched to nerve extension, but disruption of the cytoplasmic bands in Periaxin-null mice impairs Schwann cell elongation during nerve growth. By contrast, myelination proceeds normally. The capacity of wild-type and mutant Schwann cells to elongate is cell-autonomous, indicating that passive stretching can account for the lengthening of the internode during limb growth. As predicted on theoretical grounds, decreased internodal distances strikingly decrease conduction velocities and so affect motor function. We propose that microtubule-based transport in the longitudinal bands of Cajal permits internodal Schwann cells to lengthen in response to axonal growth, thus ensuring rapid nerve impulse transmission.
机译：神经冲动在脊椎动物的有髓神经的兰维耶结点传播。结节间距离已被提出来影响神经冲动传导的速度（1）。然而，缺乏直接的证据，并且可能调节髓鞘区段的长度的细胞机制尚不清楚。拉蒙·卡哈尔（Ramon y Cajal）描述了节间性施旺细胞中细胞质或小梁的纵向和横向条带，并暗示它们具有营养功能（2）。在这里，我们显示野生型神经的节间生长与神经延伸精确匹配，但是Periaxin-null小鼠中胞质带的破坏会损害神经生长过程中的雪旺氏细胞伸长。相反，髓鞘形成正常进行。野生型和突变型雪旺细胞伸长的能力是细胞自主的，这表明被动拉伸可以解释肢体生长过程中节间的延长。如理论上所预测的，节间距离的减小会显着降低传导速度，从而影响运动功能。我们提出，在Cajal的纵向带中基于微管的运输允许节间性许旺细胞响应轴突生长而延长，从而确保快速的神经冲动传递。

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