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Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-C

机译：精子细胞的分化需要细胞黏附分子-C下游的细胞极性复合体的组装

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During spermatogenesis in the mammalian testis, stem cells (spermatogonia) differentiate into spermatocytes, which subsequently undergo two consecutive meiotic divisions to give rise to haploid spermatids. These cells are initially round but progressively elongate, condense their nuclei, acquire flagellar and acrosomal structures, and shed a significant amount of their cytoplasm to form spermatozoa (the sperm cells) in a developmental cascade termed spermiogenesis(1,2). Defects in these processes will lead to a lack of mature sperm cells ( azoospermia), which is a major cause of male infertility in the human population(3). Here we report that a cell-surface protein of the immunoglobulin superfamily, junctional adhesion molecule-C (JAM-C), is critically required for the differentiation of round spermatids into spermatozoa in mice. We found that Jam-C is essential for the polarization of round spermatids, a function that we attribute to its role in the assembly of a cell polarity complex.
机译：在哺乳动物睾丸的精子发生过程中，干细胞（精原细胞）分化为精细胞，其随后经历两次连续的减数分裂，从而产生单倍体精子。这些细胞最初是圆形的，但会逐渐伸长，浓缩其细胞核，获得鞭毛和顶体结构，并脱落大量细胞质以形成称为精子发生的发育级联的精子（精子细胞）（1,2）。这些过程中的缺陷将导致缺乏成熟的精子细胞（无精子症），这是人类男性不育的主要原因（3）。在这里我们报告免疫球蛋白超家族的细胞表面蛋白，连接粘附分子-C（JAM-C），是将圆形精子分化为小鼠精子的关键条件。我们发现Jam-C对于圆形精子的极化是必不可少的，我们将此功能归因于其在细胞极性复合体组装中的作用。

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