The mosaic that is our genome

Svante Paeaebo

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The mosaic that is our genome

机译：马赛克就是我们的基因组

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The discovery of the structure of DNA, and the realization that the chemical basis of mutations is changes in the nucleotide sequence of the DNA, meant that the history of a piece of DNA could be traced by studying variation in its nucleotide sequence found in different individuals and in different species. But it was not until rapid and inexpensive methods became available for probing DNA sequence variation in many individuals that the efficient study of molecular evolution in general―and of human evolution in particular―became feasible. Thus, the development in the 1980s of techniques for efficiently scoring polymorphisms with restriction enzymes and amplifying DNA enabled the study of molecular evolution to become a truly booming enterprise. What follows is a personal and, by necessity, selective attempt to consider what the accelerating pace of exploration of human genetic variation over the past two decades has taught us about ourselves as a species, as well as some suggestions for what may be fruitful areas for future studies.

机译：DNA结构的发现以及突变的化学基础是DNA核苷酸序列的改变的认识，这意味着可以通过研究在不同个体中发现的DNA核苷酸序列的变异来追踪DNA的历史和不同的物种。但是直到快速而廉价的方法可用于研究许多个体的DNA序列变异后，对分子进化尤其是人类进化的有效研究才变得可行。因此，在1980年代，利用限制酶有效地鉴定多态性和扩增DNA的技术的发展，使得对分子进化的研究成为真正的蓬勃发展的事业。接下来是一个个人的，必要的有选择的尝试，以考虑过去二十年来人类基因变异探索的不断加快对我们自己作为一个物种的教导，以及一些关于可能取得成果的领域的建议。未来的研究。

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来源
《Nature》 |2003年第6921期|p.409-412|共4页
作者
Svante Paeaebo;
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作者单位

Max Planck Institute for Evolutionary Anthropology, Deutseher Platz 6, D-04103 Leipzig, Germany;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Nucleotide sequence of the 3'-terminal region of the genome of the azuki bean mosaic strain of the bean common mosaic virus and its phylogenetic relationship to viruses in the bean common mosaic virus group [J] . Takahashi Y, Kamagata Y, Matsumura T, 日本植物病理学会报 . 1998,第5期

机译：豆普通花叶病毒组小豆花叶病毒株基因组3'-末端的核苷酸序列及其与病毒的亲缘关系
2. Expression of concern: Sequences enhancing cassava mosaic disease symptoms occur in the cassava genome and are associated with South African cassava mosaic virus infection by A. T. Maredza, F. Allie, G. Plata, M. E. C. Rey [J] . Hohmann Stefan Molecular genetics and genomics: MGG . 2016,第3期

机译：关注的表达：增强木薯花叶病症状的序列出现在木薯基因组中，并与A. T. Maredza，F。Allie，G。Plata，M。E. C. Rey感染南非木薯花叶病毒有关。
3. Sequences enhancing cassava mosaic disease symptoms occur in the cassava genome and are associated with South African cassava mosaic virus infection [J] . Maredza A. T., Allie F., Plata G., Molecular genetics and genomics: MGG . 2016,第3期

机译：增强木薯花叶病症状的序列出现在木薯基因组中，并与南非木薯花叶病毒感染有关
4. INFERRING GENOME-WIDE MOSAIC STRUCTURE [C] . QI ZHANG, WEI WANG, LEONARD MCMILLAN, PSB;Pacific symposium on biocomputing; 20090105-09;20090105-09; Kohala Coast, HI(US);Kohala Coast, HI(US) . 2009

机译：推论全基因组马赛克结构
5. MASKING OF TOBACCO MOSAIC VIRUS RNA GENOME IN THE COAT PROTEIN OF BARLEY STRIPE MOSAIC VIRUS. [D] . DODDS, JAMES ALLAN -1

机译：大麦条纹MOS病毒外壳蛋白中烟草烟草病毒RNA基因组的掩蔽。
6. Historical overview of research on the tobacco mosaic virus genome: genome organization infectivity and gene manipulation. [O] . Y Okada 1999

机译：烟草花叶病毒基因组研究的历史回顾：基因组组织感染性和基因操作。
7. Nuclotide Sequence of the 3'-terminal Region of the Genome of the Azuki Bean Mosaic Strain of the Bean Common Mosaic Virus and Its Phylogenetic Relationship to Viruses in the Bean Common Mosaic Virus Group. [O] . Yoko TAKAHASHI, Yasuyo KAMAGATA, Takeshi MATSUMURA, 1998

机译：豆类常见叶片病毒的氮杂豆果皮菌株的基因组3'-末端区域的核酸序列及其系统发育关系与豆类常见的马赛克病毒组病毒。
8. Characterization of a defective interfering RNA that contains a mosaic of a plant viral genome. Final report [R] . Morris, T. J., Jackson, A. O. 1991

机译：表征含有植物病毒基因组镶嵌的有缺陷的干扰RNa。总结报告

The mosaic that is our genome

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