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Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

机译：Bmi-1决定正常和白血病干细胞的增殖能力

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An emerging concept in the field of cancer biology is that a rare population of 'tumour stem cells' exists among the heterogeneous group of cells that constitute a tumour. This concept, best described with human leukaemia, indicates that stem cell function ( whether normal or neoplastic) might be defined by a common set of critical genes. Here we show that the Polycomb group gene Bmi-1 has a key role in regulating the proliferative activity of normal stem and progenitor cells. Most importantly, we provide evidence that the proliferative potential of leukaemic stem and progenitor cells lacking Bmi-1 is compromised because they eventually undergo proliferation arrest and show signs of differentiation and apoptosis, leading to transplant failure of the leukaemia. Complementation studies showed that Bmi-1 completely rescues these proliferative defects. These studies therefore indicate that Bmi-1 has an essential role in regulating the proliferative activity of both normal and leukaemic stem cells. [References: 24]
机译：癌症生物学领域中的一个新兴概念是，在构成肿瘤的异质细胞群中，存在罕见的“肿瘤干细胞”群体。用人类白血病最好地描述了这个概念，表明干细胞功能（正常或肿瘤性）可能由一组常见的关键基因来定义。在这里，我们显示Polycomb组基因Bmi-1在调节正常干细胞和祖细胞的增殖活性中具有关键作用。最重要的是，我们提供的证据表明缺乏Bmi-1的白血病干细胞和祖细胞的增殖潜力受到损害，因为它们最终经历了增殖停滞并显示出分化和凋亡的迹象，从而导致白血病的移植失败。补充研究表明，Bmi-1可以完全挽救这些增殖缺陷。因此，这些研究表明Bmi-1在调节正常干细胞和白血病干细胞的增殖活性中起着至关重要的作用。 [参考：24]

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