Switched on to RNA

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Switched on to RNA

机译：开启RNA

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One day in 1999, molecular biologist Ron Breaker interrupted his lab's weekly meeting to issue a challenge: to discover whether their synthetic RNA biosensors were original, or whether nature got there first. Breaker's team, at Yale University in New Haven, Connecticut, was crafting molecular sensors out of RNA that changes shape when it binds to a specific molecule. The team's aim was to produce miniature devices that could, for example, monitor the biochemical secretions of living cells. These sensors were working so well that Breaker couldn't believe that evolution had overlooked the same mechanism. Breaker was remarkably prescient. Similar sensors, it turned out, had been staring biologists in the face for nearly 30 years. In an eye-opening series of experiments, Breaker's team has revealed that these RNA sensors, dubbed'riboswitches', represent a previously overlooked mechanism of gene regulation. "We can explain a lot of the unexplained findings that have appeared in the literature over the years," Breaker says.

机译：在1999年的一天，分子生物学家罗恩·布雷克（Ron Breaker）中断了他的实验室的每周例会，提出了一个挑战：发现他们的合成RNA生物传感器是原始的，还是自然界首先到达的。位于康涅狄格州纽黑文市耶鲁大学的Breaker团队正在利用RNA合成分子传感器，当RNA与特定分子结合时，RNA会改变形状。该小组的目的是生产微型设备，例如，可以监测活细胞的生化分泌物。这些传感器运行良好，以至于Breaker无法相信进化忽略了相同的机制。断路器非常有先见之明。事实证明，类似的传感器已经盯着生物学家近30年了。在一系列令人大开眼界的实验中，Breaker的团队揭示了这些被称为“核糖开关”的RNA传感器代表了以前被忽略的基因调控机制。 Breaker说：“我们可以解释多年来文献中出现的许多无法解释的发现。”

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《Nature》 |2003年第6955期|p.232-233|共2页
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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专利

1. Heterologous RNA replication enhancer stimulates in vitro RNA synthesis and template-switching by the carmovirus, but not by the tombusvirus, RNA-dependent RNA polymerase: implication for modular evolution of RNA viruses. [J] . Cheng CP, Panavas T, Luo G, Virology . 2005,第1期

机译：异源RNA复制增强剂通过carmovirus刺激体外RNA合成和模板转换，但不通过鼓膜病毒刺激RNA依赖性RNA聚合酶：暗示RNA病毒的模块化进化。
2. RNA-conjugated template-switching RT-PCR method for generating an Escherichia coli cDNA library for small RNAs [J] . Ko JH, Lee Y Journal of Microbiological Methods . 2006,第3期

机译：RNA缀合的模板切换RT-PCR方法用于生成小型RNA的大肠杆菌cDNA文库
3. Method and apparatus to facilitate on-demand wireless Quality of Service (QOS) in a vehicle by switching between the Telematics system and an advanced external NAD or personal mobile station by using a switching decision algorithm [J] . Research Disclosure . 2020,第669期

机译：通过使用切换决策算法在远程信息处理系统和高级外部NAD或个人移动台之间切换，通过在远程信息处理系统和高级外部NAD或个人移动站之间促进车辆中的不需要服务（QoS）的方法和装置
4. A Full Spectrum Analysis of a Jeffcott Rotor with Switching Crack in the Presence of Internal and External Damping [C] . D. K. Roy, Rajiv Tiwari International Conference on Vibration Problems . 2020

机译：在存在内部和外部阻尼的情况下具有开关裂缝的Jeffcott转子的全谱分析
5. Neural Network Architecture with External Memory and Domain-aware Weight Switching Mechanism [D] . Patel, Deep Chittranjan. 2020

机译：具有外部存储器的神经网络架构和域感知权重切换机制
6. RNA-RNA recombination in Sindbis virus: roles of the 3 conserved motif poly(A) tail and nonviral sequences of template RNAs in polymerase recognition and template switching. [O] . K R Hill, M Hajjou, J Y Hu, 1997

机译：Sindbis病毒中的RNA-RNA重组：模板RNA的3保守基序poly（A）尾部和非病毒序列在聚合酶识别和模板转换中的作用。
7. Heterologous RNA replication enhancer stimulates in vitro RNA synthesis and template-switching by the carmovirus, but not by the tombusvirus, RNA-dependent RNA polymerase: Implication for modular evolution of RNA viruses [O] . Cheng Chi-Ping, Panavas Tadas, Luo Guangxiang, 2005

机译：异源RNA复制增强剂通过carmovirus刺激体外RNA合成和模板转换，但不通过鼓膜病毒刺激，RNA依赖性RNA聚合酶：对RNA病毒模块化进化的影响
8. On the Race-Free and Minimal Cost Coding of the Internal States in Computer Aided Design of Sequential Switching Systems. On the Programming System RENDIS-s for the Design of Sequential Switching Systems. [R] . Hallbauer, G., Heltzig, H. F., Hummitzsch, P. 1975

机译：捕获顺序切换系统。关于顺序切换系统设计的编程系统。

Switched on to RNA

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