Folding proteins in fatal ways

Dennis J. Selkoe

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Folding proteins in fatal ways

机译：以致命的方式折叠蛋白质

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Human diseases characterized by insoluble extracellular deposits of proteins have been recognized for almost two centuries. Such amyloidoses were once thought to represent arcane secondary phenomena of questionable pathogenic significance. But it is has now become clear that many different proteins can misfold and form extracellular or intracellular aggregates that initiate profound cellular dysfunction. Particularly challenging examples of such disorders occur in the post-mitotic environment of the neuron and include Alzheimer's and Parkinson's diseases. Understanding some of the principles of protein folding has helped to explain how such diseases arise, with attendant therapeutic insights.

机译：以蛋白质的不溶性细胞外沉积为特征的人类疾病已被公认近两个世纪。这种淀粉样糖曾经被认为代表了具有可疑的致病意义的奥秘继发现象。但是，现在已经清楚的是，许多不同的蛋白质可以错误折叠并形成细胞外或细胞内聚集体，从而引发严重的细胞功能障碍。这种疾病的特别具有挑战性的例子发生在神经元的有丝分裂后环境中，包括阿尔茨海默氏病和帕金森氏病。了解蛋白质折叠的某些原理有助于解释这种疾病的产生方式，并具有相关的治疗见解。

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来源
《Nature》 |2003年第6968期|p.900-904|共5页
作者
Dennis J. Selkoe;
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作者单位

Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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2. Is Protein Folding Rate Dependent on Number of Folding Stages? Modeling of Protein Folding with Ferredoxin-Like Fold [J] . O. V. Galzitskaya Biochemistry . 2010,第6期

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3. Analyses of the folding properties of ferredoxin-like fold proteins by means of a coarse-grained Gō model: Relationship between the free energy profiles and folding cores [J] . SugitaM., KikuchiT. Proteins: Structure, Function, and Genetics . 2014,第6期

机译：粗粒Gō模型分析铁氧还蛋白样折叠蛋白的折叠特性：自由能谱与折叠核之间的关系
4. Atomic Structure of Bordetella Bacteriophage Reveals a Jellyroll Fold in CementProtein and a Topologically Distinct HK97-like Fold in Major Capsid Protein [C] . Xing Zhang, Huatao Guo, Lei Jin, Microscopy Society of America Annual Meeting;Microanalysis Society Annual meeting;International Metallographic Society Annual meeting . 2012

机译：博德特氏菌噬菌体的原子结构揭示了水泥蛋白中的果冻折叠和主要衣壳蛋白中拓扑不同的HK97样折叠。
5. Elucidating the origins of cooperativity in protein folding and detecting parallel folding pathways with consensus Ankyrin Repeat proteins [D] . Aksel, Tural 2012

机译：阐明蛋白质折叠中协同作用的起源，并通过锚蛋白重复序列蛋白检测平行折叠途径
6. Hydrophobic folding units at protein-protein interfaces: implications to protein folding and to protein-protein association. [O] . C. J. Tsai, R. Nussinov 1997

机译：蛋白质-蛋白质界面的疏水折叠单元：对蛋白质折叠和蛋白质-蛋白质缔合的影响。
7. 2P110 Study of the folding mechanism of a mini-protein FSD-EY with a ββα fold by the multicanonical molecular dynamics(Proteins-stability, folding, and other physicochemical properties,Poster Presentations) [O] . Tadaomi Furuta, Tohru Terada 2007

机译：2P110通过多甘选分子动力学（蛋白质 - 稳定，折叠和其他物理化学，海报展示）ββα折叠含有ββα的折叠机制的折叠机制

Folding proteins in fatal ways

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