Regenerating the damaged central nervous system

Philip J. Horner; Fred H. Gage

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Regenerating the damaged central nervous system

机译：再生受损的中枢神经系统

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It is self-evident that the adult mammalian brain and spinal cord do not regenerate after injury, but recent discoveries have forced a reconsideration of this accepted principle. Advances in our understanding of how the brain develops have provided a rough blueprint for how we may bring about regeneration in the damaged brain. Studies in developmental neurobiology, intracellular signalling and neuroimmunology are bringing the regeneration field closer to success. Notwithstanding these advances, clear and indisputable evidence for adult functional regeneration remains to be shown.

机译：不言而喻，成年哺乳动物的大脑和脊髓在受伤后不会再生，但是最近的发现迫使人们重新考虑这一公认的原则。我们对大脑发育的理解的进步为我们如何使受损的大脑再生提供了粗略的蓝图。在发育神经生物学，细胞内信号传导和神经免疫学方面的研究使再生领域更接近成功。尽管取得了这些进展，但仍存在关于成人功能再生的明确且无可争议的证据。

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《Nature》 |2000年第6807期|p.963-970|共8页
作者
Philip J. Horner; Fred H. Gage;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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6. Rho/ROCK pathway and neural regeneration: a potential therapeutic target for central nervous system and optic nerve damage [O] . Hai-Bo Tan, Yi-Sheng Zhong, Yu Cheng, 2011

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7. Expressão do complexo de histocompatilidade principal de classe I (MHC I) no sistema nervoso central: plasticidade sináptica e regeneração Expresión del complejo principal de histocompatibilidad de clase I (MHC I) en el sistema nervioso central: plasticidad sináptica y regeneración Expression of class I major histocompatibility complex (MHC I) in the central nervous system: role in synaptic plasticity and regeneration [O] . Renata Graciele Zanon, Amanda Emirandetti, Gustavo Ferreira Simões, 2010

机译：中枢神经系统中I类主要组织相容性复合体（mHC I）的表达：I型主要复杂性的突触可塑性和再生表达（mHC I）中枢神经系统的组织相容性：I类主要的突触可塑性和再生表达组织相容性复合体（mHC I）在中枢神经系统中：在突触可塑性和再生中的作用
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机译：由异常神经产生的外部因素在非再生中枢神经系统中引发再生反应：纯化和作用方式。

Regenerating the damaged central nervous system

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