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Neural signatures of sleep in zebrafish

机译：斑马鱼的睡眠神经特征

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摘要

Slow-wave sleep and rapid eye movement (or paradoxical) sleep have been found in mammals, birds and lizards, but it is unclear whether these neuronal signatures are found in non-amniotic vertebrates. Here we develop non-invasive fluorescence-based polysomnography for zebrafish, and show-using unbiased, brain-wide activity recording coupled with assessment of eye movement, muscle dynamics and heart rate-that there are at least two major sleep signatures in zebrafish. These signatures, which we term slow bursting sleep and propagating wave sleep, share commonalities with those of slow-wave sleep and paradoxical or rapid eye movement sleep, respectively. Further, we find that melanin-concentrating hormone signalling (which is involved in mammalian sleep) also regulates propagating wave sleep signatures and the overall amount of sleep in zebrafish, probably via activation of ependymal cells. These observations suggest that common neural signatures of sleep may have emerged in the vertebrate brain over 450 million years ago.
机译：在哺乳动物，鸟类和蜥蜴中已发现慢波睡眠和快速眼动（或自相矛盾）睡眠，但尚不清楚在非羊水脊椎动物中是否发现了这些神经元信号。在这里，我们为斑马鱼开发了基于非侵入式荧光的多导睡眠图，并展示了使用无偏见的全脑活动记录以及对眼球运动，肌肉动力学和心率的评估，斑马鱼至少有两个主要的睡眠特征。这些信号，我们称为慢速猝发睡眠和传播性波睡眠，分别与慢波睡眠和反常或快速眼动睡眠共享。此外，我们发现，黑色素浓缩激素信号传导（参与哺乳动物的睡眠）也可能通过激活室管膜细胞来调节斑马鱼的传播波睡眠信号和睡眠总量。这些观察结果表明，超过4.5亿年前，脊椎动物大脑中已经出现了常见的睡眠神经特征。

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  • 来源
    《Nature》 |2019年第7764期|198-204|共7页
  • 作者

    Leung Louis C.; Wang Gordon X.; Madelaine Romain; Skariah Gemini; Kawakami Koichi; Deisseroth Karl; Urban Alexander E.; Mourrain Philippe;

  • 作者单位

    Stanford Univ, Ctr Sleep Sci & Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA;

    Stanford Univ, Ctr Sleep Sci & Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA;

    Stanford Univ, Ctr Sleep Sci & Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA;

    Stanford Univ, Ctr Sleep Sci & Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA;

    Sokendai, Natl Inst Genet, Div Mol & Dev Biol, Mishima, Shizuoka, Japan|Sokendai, Dept Genet, Mishima, Shizuoka, Japan;

    Howard Hughes Med Inst, Stanford, CA USA|Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA|Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA;

    Stanford Univ, Ctr Genom & Personalized Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA;

    Stanford Univ, Ctr Sleep Sci & Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA|Ecole Normale Super, INSERM 1024, Paris, France;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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