Neural signatures of sleep in zebrafish

Leung Louis C.; Wang Gordon X.; Madelaine Romain; Skariah Gemini; Kawakami Koichi; Deisseroth Karl; Urban Alexander E.; Mourrain Philippe

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Neural signatures of sleep in zebrafish

机译：斑马鱼睡眠的神经签名

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Slow-wave sleep and rapid eye movement (or paradoxical) sleep have been found in mammals, birds and lizards, but it is unclear whether these neuronal signatures are found in non-amniotic vertebrates. Here we develop non-invasive fluorescence-based polysomnography for zebrafish, and show-using unbiased, brain-wide activity recording coupled with assessment of eye movement, muscle dynamics and heart rate-that there are at least two major sleep signatures in zebrafish. These signatures, which we term slow bursting sleep and propagating wave sleep, share commonalities with those of slow-wave sleep and paradoxical or rapid eye movement sleep, respectively. Further, we find that melanin-concentrating hormone signalling (which is involved in mammalian sleep) also regulates propagating wave sleep signatures and the overall amount of sleep in zebrafish, probably via activation of ependymal cells. These observations suggest that common neural signatures of sleep may have emerged in the vertebrate brain over 450 million years ago.

机译：在哺乳动物，鸟类和蜥蜴中发现了慢波睡眠和快速眼球运动（或矛盾的）睡眠，但目前尚不清楚这些神经元签名是否存在于非羊虫脊椎动物中。在这里，我们为斑马鱼开发非侵入性荧光的多肌肉摄影，并展示使用无偏的脑宽活动记录，再加上眼球运动，肌肉动力学和心率的评估 - 斑马鱼中至少有两个主要睡眠签名。这些签名，我们术语缓慢衰退和繁殖波睡眠，分别与慢波睡眠和矛盾或快速眼睛运动睡眠的共性。此外，我们发现黑色素浓缩的激素信号（参与哺乳动物睡眠）还调节斑马鱼中的睡眠睡眠签名和睡眠总量，可能是通过激活突出细胞。这些观察结果表明，在4.5亿年前，脊椎动物的常见神经签名可能已经出现在脊椎动物。

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《Nature》 |2019年第7764期|198-204|共7页
作者
Leung Louis C.; Wang Gordon X.; Madelaine Romain; Skariah Gemini; Kawakami Koichi; Deisseroth Karl; Urban Alexander E.; Mourrain Philippe;
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作者单位

Stanford Univ Ctr Sleep Sci & Med Dept Psychiat & Behav Sci Stanford CA 94305 USA;

Stanford Univ Ctr Sleep Sci & Med Dept Psychiat & Behav Sci Stanford CA 94305 USA;

Stanford Univ Ctr Sleep Sci & Med Dept Psychiat & Behav Sci Stanford CA 94305 USA;

Stanford Univ Ctr Sleep Sci & Med Dept Psychiat & Behav Sci Stanford CA 94305 USA;

Sokendai Natl Inst Genet Div Mol & Dev Biol Mishima Shizuoka Japan|Sokendai Dept Genet Mishima Shizuoka Japan;

Howard Hughes Med Inst Stanford CA USA|Stanford Univ Dept Bioengn Stanford CA 94305 USA|Stanford Univ Dept Psychiat & Behav Sci Stanford CA 94305 USA;

Stanford Univ Ctr Genom & Personalized Med Dept Psychiat & Behav Sci Stanford CA 94305 USA;

Stanford Univ Ctr Sleep Sci & Med Dept Psychiat & Behav Sci Stanford CA 94305 USA|Ecole Normale Super INSERM 1024 Paris France;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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1. Neural signatures of sleep in zebrafish [J] . Leung Louis C., Wang Gordon X., Madelaine Romain, Nature . 2019,第7764期

机译：斑马鱼的睡眠神经特征
2. METABOLIC AGING AND SLEEP LOSS: METABOLITE SIGNATURES LINK SLEEP DEPRIVATION AND AGING ACROSS TISSUES [J] . Sengupta A., Tudor J. C., Cusmano D., Sleep . 2020,第Suppla1期

机译：代谢衰老和睡眠损失：代谢物签名链接睡眠剥夺和组织衰老
3. Differential spectrum approach to uncovering the electroencephalographic signatures of the opponent driving forces for sleep and wake underlying alternations of sleep and wake states [J] . Putilov Arcady A. Biomedical signal processing and control . 2018,第jana期

机译：差分频谱方法可揭示对手睡眠和醒来驱动力的脑电图特征
4. Two-photon high-speed light-sheet volumetric imaging of brain activity during sleep in zebrafish larvae [C] . Giuseppe de Vito, Chiara Fornetto, Pietro Ricci, Conference on Neural Imaging and Sensing;Society of Photo-Optical Instrumentation Engineers . 2020

机译：斑马鱼幼虫睡眠期间大脑活动的双光子高速光片体积成像
5. How “Sleeping on It” Works: The Cognitive Mechanisms and Neural Signatures of Sleep-Facilitated Problem Solving [D] . Sanders, Kristin Eileen Grunewald. 2019

机译：如何“睡觉”作品：睡眠促进问题解决的认知机制和神经签名
6. Loss of zebrafish atp6v1e1b encoding a subunit of vacuolar ATPase recapitulates human ARCL type 2C syndrome and identifies multiple pathobiological signatures [O] . Lore Pottie, Wouter Van Gool, Michiel Vanhooydonck, 2021

机译：斑马鱼ATP6V1E1B的损失编码真空ATP酶的亚基重新承诺人ARCL型2C综合征并鉴定多种病原体签名
7. Loss of zebrafish atp6v1e1b, encoding a subunit of vacuolar ATPase, recapitulates human ARCL type 2C syndrome and identifies multiple pathobiological signatures [O] . Lore Pottie, Wouter Van Gool, Michiel Vanhooydonck, 2021

机译：斑马鱼ATP6V1E1B的损失，编码真空ATP酶的亚基，重新承诺人ARCL型2C综合征，并鉴定多种病原体签名

Neural signatures of sleep in zebrafish

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