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首页> 外文期刊>Nature >Microbiota-derived lantibiotic restores resistance against vancomycin-resistant Enterococcus
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Microbiota-derived lantibiotic restores resistance against vancomycin-resistant Enterococcus

机译：微生物来源的羊毛硫抗生素可恢复对耐万古霉素肠球菌的耐药性

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摘要

Intestinal commensal bacteria can inhibit dense colonization of the gut by vancomycin-resistant Enterococcus faecium (VRE), a leading cause of hospital-acquired infections(1,2). A four-strained consortium of commensal bacteria that contains Blautia producta BPSCSK can reverse antibiotic-induced susceptibility to VRE infection(3). Here we show that BPSCSK reduces growth of VRE by secreting a lantibiotic that is similar to the nisin-A produced by Lactococcus lactis. Although the growth of VRE is inhibited by BPSCSK and L. lactis in vitro, only BPSCSK colonizes the colon and reduces VRE density in vivo. In comparison to nisin-A, the BPSCSK lantibiotic has reduced activity against intestinal commensal bacteria. In patients at high risk of VRE infection, high abundance of the lantibiotic gene is associated with reduced density of E. faecium. In germ-free mice transplanted with patient-derived faeces, resistance to VRE colonization correlates with abundance of the lantibiotic gene. Lantibiotic-producing commensal strains of the gastrointestinal tract reduce colonization by VRE and represent potential probiotic agents to re-establish resistance to VRE.
机译：肠道共生细菌可抑制耐万古霉素的粪便肠球菌（VRE）致肠的密集定植，这是医院获得性感染的主要原因（1,2）。含有产布鲁氏菌BPSCSK的四株共生细菌财团可以逆转抗生素引起的对VRE感染的易感性（3）。在这里，我们显示BPSCSK通过分泌类似于乳酸乳球菌产生的乳链菌肽A的羊毛硫抗生素来减少VRE的生长。尽管BPSCSK和乳酸乳球菌在体外抑制VRE的生长，但只有BPSCSK才能在结肠内定居并降低体内的VRE密度。与乳链菌肽A相比，BPSCSK羊毛硫抗生素对肠道共生细菌的活性降低。在具有VRE感染高风险的患者中，羊毛硫抗生素基因的高丰度与粪肠球菌的密度降低有关。在移植有患者粪便的无菌小鼠中，对VRE定植的抗性与羊毛硫抗生素基因的丰度相关。产生胃肠道的产生羊毛硫抗生素的共生菌株减少了VRE的定植，并代表了潜在的益生菌制剂，可重新建立对VRE的抗性。

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  • 来源
    《Nature》 |2019年第7771期|665-669|共5页
  • 作者

    Kim Sohn G.; Becattini Simone; Moody Thomas U.; Shliaha Pavel V.; Littmann Eric R.; Seok Ruth; Gjonbalaj Mergim; Eaton Vincent; Fontana Emily; Amoretti Luigi; Wright Roberta; Caballero Silvia; Wang Zhong-Min X.; Jung Hea-Jin; Morjaria Sejal M.; Leiner Ingrid M.; Qin Weige; Ramos Ruben J. J. F.; Cross Justin R.; Narushima Seiko; Honda Kenya; Peled Jonathan U.; Hendrickson Ronald C.; Taur Ying; van den Brink Marcel R. M.; Pamer Eric G.;

  • 作者单位

    Mem Sloan Kettering Canc Ctr, Immunol Program, Sloan Kettering Inst, 1275 York Ave, New York, NY 10021 USA|Weill Cornell Med Coll, New York, NY 10065 USA;

    Mem Sloan Kettering Canc Ctr, Immunol Program, Sloan Kettering Inst, 1275 York Ave, New York, NY 10021 USA;

    Mem Sloan Kettering Canc Ctr, Immunol Program, Sloan Kettering Inst, 1275 York Ave, New York, NY 10021 USA|Mem Sloan Kettering Canc Ctr, Lucille Castori Ctr Microbes Inflammat & Canc, 1275 York Ave, New York, NY 10021 USA;

    Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Microchem & Prote Core Lab, 1275 York Ave, New York, NY 10021 USA;

    Mem Sloan Kettering Canc Ctr, Lucille Castori Ctr Microbes Inflammat & Canc, 1275 York Ave, New York, NY 10021 USA;

    Mem Sloan Kettering Canc Ctr, Immunol Program, Sloan Kettering Inst, 1275 York Ave, New York, NY 10021 USA;

    Mem Sloan Kettering Canc Ctr, Immunol Program, Sloan Kettering Inst, 1275 York Ave, New York, NY 10021 USA;

    Mem Sloan Kettering Canc Ctr, Immunol Program, Sloan Kettering Inst, 1275 York Ave, New York, NY 10021 USA;

    Mem Sloan Kettering Canc Ctr, Lucille Castori Ctr Microbes Inflammat & Canc, 1275 York Ave, New York, NY 10021 USA;

    Mem Sloan Kettering Canc Ctr, Lucille Castori Ctr Microbes Inflammat & Canc, 1275 York Ave, New York, NY 10021 USA;

    Mem Sloan Kettering Canc Ctr, Lucille Castori Ctr Microbes Inflammat & Canc, 1275 York Ave, New York, NY 10021 USA;

    Mem Sloan Kettering Canc Ctr, Immunol Program, Sloan Kettering Inst, 1275 York Ave, New York, NY 10021 USA|Weill Cornell Med Coll, New York, NY 10065 USA;

    Mem Sloan Kettering Canc Ctr, Immunol Program, Sloan Kettering Inst, 1275 York Ave, New York, NY 10021 USA;

    Mem Sloan Kettering Canc Ctr, Immunol Program, Sloan Kettering Inst, 1275 York Ave, New York, NY 10021 USA;

    Mem Sloan Kettering Canc Ctr, Dept Med, Infect Dis Serv, 1275 York Ave, New York, NY 10021 USA;

    Mem Sloan Kettering Canc Ctr, Immunol Program, Sloan Kettering Inst, 1275 York Ave, New York, NY 10021 USA|Mem Sloan Kettering Canc Ctr, Lucille Castori Ctr Microbes Inflammat & Canc, 1275 York Ave, New York, NY 10021 USA;

    Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Donald B & Catherine C Marron Canc Metab Ctr, 1275 York Ave, New York, NY 10021 USA;

    Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Donald B & Catherine C Marron Canc Metab Ctr, 1275 York Ave, New York, NY 10021 USA;

    Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Donald B & Catherine C Marron Canc Metab Ctr, 1275 York Ave, New York, NY 10021 USA;

    RIKEN, Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan;

    RIKEN, Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan|Keio Univ, Med & Chem Innovat Ctr, JSR, Tokyo, Japan|RIKEN, Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan;

    Weill Cornell Med Coll, New York, NY 10065 USA|Mem Sloan Kettering Canc Ctr, Dept Med, Adult Bone Marrow Transplant Serv, 1275 York Ave, New York, NY 10021 USA;

    Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Microchem & Prote Core Lab, 1275 York Ave, New York, NY 10021 USA|Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Mol Pharmacol Program, 1275 York Ave, New York, NY 10021 USA;

    Mem Sloan Kettering Canc Ctr, Dept Med, Infect Dis Serv, 1275 York Ave, New York, NY 10021 USA;

    Mem Sloan Kettering Canc Ctr, Immunol Program, Sloan Kettering Inst, 1275 York Ave, New York, NY 10021 USA|Weill Cornell Med Coll, New York, NY 10065 USA|Mem Sloan Kettering Canc Ctr, Dept Med, Adult Bone Marrow Transplant Serv, 1275 York Ave, New York, NY 10021 USA;

    Mem Sloan Kettering Canc Ctr, Immunol Program, Sloan Kettering Inst, 1275 York Ave, New York, NY 10021 USA|Weill Cornell Med Coll, New York, NY 10065 USA|Mem Sloan Kettering Canc Ctr, Lucille Castori Ctr Microbes Inflammat & Canc, 1275 York Ave, New York, NY 10021 USA|Mem Sloan Kettering Canc Ctr, Dept Med, Infect Dis Serv, 1275 York Ave, New York, NY 10021 USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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