• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature >Immunity to commensal papillomaviruses protects against skin cancer
【24h】

Immunity to commensal papillomaviruses protects against skin cancer

机译：免疫共乳头瘤病毒可预防皮肤癌

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Immunosuppression increases the risk of cancers that are associated with viral infection(1). In particular, the risk of squamous cell carcinoma of the skin-which has been associated with beta human papillomavirus (beta-HPV) infection-is increased by more than 100-fold in immunosuppressed patients(2-4). Previous studies have not established a causative role for HPVs in driving the development of skin cancer. Here we show that T cell immunity against commensal papillomaviruses suppresses skin cancer in immunocompetent hosts, and the loss of this immunity-rather than the oncogenic effect of HPVs-causes the markedly increased risk of skin cancer in immunosuppressed patients. To investigate the effects of papillomavirus on carcinogen-driven skin cancer, we colonized several strains of immunocompetent mice with mouse papillomavirus type 1 (MmuPV1)(5). Mice with natural immunity against MmuPV1 after colonization and acquired immunity through the transfer of T cells from immune mice or by MmuPV1 vaccination were protected against skin carcinogenesis induced by chemicals or by ultraviolet radiation in a manner dependent on CD8(+) T cells. RNA and DNA in situ hybridization probes for 25 commensal beta-HPVs revealed a significant reduction in viral activity and load in human skin cancer compared with the adjacent healthy skin, suggesting a strong immune selection against virus-positive malignant cells. Consistently, E7 peptides from beta-HPVs activated CD8(+) T cells from unaffected human skin. Our findings reveal a beneficial role for commensal viruses and establish a foundation for immune-based approaches that could block the development of skin cancer by boosting immunity against the commensal HPVs present in all of our skin.
机译：免疫抑制会增加与病毒感染相关的癌症的风险（1）。特别是，与免疫球蛋白B抑制的人皮肤乳头状病毒（β-HPV）感染相关的皮肤鳞状细胞癌的风险增加了100倍以上（2-4）。先前的研究尚未确定HPV在驱动皮肤癌发展中的致病作用。在这里，我们显示针对共乳头瘤病毒的T细胞免疫抑制了具有免疫能力的宿主中的皮肤癌，这种免疫力的丧失（而不是HPV的致癌作用）导致免疫抑制患者皮肤癌的风险显着增加。为了研究乳头瘤病毒对致癌物驱动的皮肤癌的影响，我们在小鼠乳头瘤病毒1型（MmuPV1）（5）的几只具有免疫能力的小鼠中定殖。在定居后对MmuPV1具有天然免疫力并通过从免疫小鼠转移T细胞或通过MmuPV1疫苗获得免疫力的小鼠，可以免受化学物质或紫外线辐射诱导的皮肤致癌作用，依赖于CD8（+）T细胞。与相邻的健康皮肤相比，针对25种共生β-HPV的RNA和DNA原位杂交探针显示，人类皮肤癌的病毒活性和载量显着降低，这表明针对病毒阳性恶性细胞的免疫选择非常强。一致地，来自β-HPV的E7肽激活了未受影响的人类皮肤的CD8（+）T细胞。我们的发现揭示了共生病毒的有益作用，并为基于免疫的方法奠定了基础，该方法可通过增强针对我们所有皮肤中存在的共生HPV的免疫力来阻止皮肤癌的发展。

著录项

  • 来源
    《Nature》 |2019年第7783期|519-522|共4页
  • 作者

    Strickley John D.; Messerschmidt Jonathan L.; Awad Mary E.; Li Tiancheng; Hasegawa Tatsuya; Dat Thinh Ha; Nabeta Henry W.; Bevins Paul A.; Ngo Kenneth H.; Asgari Maryam M.; Nazarian Rosalynn M.; Neel Victor A.; Jenson Alfred Bennett; Joh Joongho; Demehri Shadmehr;

  • 作者单位

    Massachusetts Gen Hosp Ctr Canc Res Ctr Canc Immunol Boston MA 02114 USA|Massachusetts Gen Hosp Ctr Canc Res Cutaneous Biol Res Ctr Boston MA 02114 USA|Harvard Med Sch Boston MA 02115 USA|Univ Louisville James Graham Brown Canc Ctr Louisville KY 40292 USA|Univ Louisville Dept Med Louisville KY 40292 USA;

    Massachusetts Gen Hosp Ctr Canc Res Ctr Canc Immunol Boston MA 02114 USA|Massachusetts Gen Hosp Ctr Canc Res Cutaneous Biol Res Ctr Boston MA 02114 USA|Harvard Med Sch Boston MA 02115 USA;

    Univ Louisville James Graham Brown Canc Ctr Louisville KY 40292 USA|Univ Louisville Dept Med Louisville KY 40292 USA;

    Harvard Med Sch Boston MA 02115 USA|Massachusetts Gen Hosp Dept Dermatol Boston MA 02114 USA;

    Harvard Med Sch Boston MA 02115 USA|Massachusetts Gen Hosp Dept Pathol Boston MA 02114 USA;

    Univ Louisville James Graham Brown Canc Ctr Louisville KY 40292 USA;

    Univ Louisville James Graham Brown Canc Ctr Louisville KY 40292 USA|Univ Louisville Dept Med Louisville KY 40292 USA|Univ Louisville Ctr Predict Med Louisville KY 40292 USA;

    Massachusetts Gen Hosp Ctr Canc Res Ctr Canc Immunol Boston MA 02114 USA|Massachusetts Gen Hosp Ctr Canc Res Cutaneous Biol Res Ctr Boston MA 02114 USA|Harvard Med Sch Boston MA 02115 USA|Massachusetts Gen Hosp Dept Dermatol Boston MA 02114 USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号