Lipid carrier breaks barrier in Alzheimer's disease

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Lipid carrier breaks barrier in Alzheimer's disease

机译：脂质载体打破阿尔茨海默氏病的障碍

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People who carry the gene variant APOE4 are at higher-than-average risk of developing Alzheimer's disease. It emerges that this variant is linked to defects in the blood-brain barrier and subsequent cognitive decline.A link between APOE4 and breakdown of the blood-brain barrier.

机译：携带基因变体APOE4的人患阿尔茨海默氏病的风险高于平均水平。结果表明，这种变异与血脑屏障的缺陷和随后的认知能力下降有关.APOE4与血脑屏障的破坏之间存在联系。

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《Nature》 |2020年第7806期|31-32|共2页
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作者单位

Weill Cornell Med Feil Family Brain & Mind Res Inst New York NY 10065 USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
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关键词
Neurodegeneration; Alzheimer's disease;

机译：神经变性;阿尔茨海默氏病;

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专利

1. Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease [J] . Halliday Matthew R., Rege Sanket V., Ma Qingyi, Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism . 2016,第1期

机译：载脂蛋白E4携带阿尔茨海默氏病的患者加速周细胞变性和血脑屏障破坏
2. Serum zinc, copper, insulin and lipids in Alzheimer's disease epsilon 4 apolipoprotein E allele carriers (see comments) [J] . Gonzalez C, Martin T, Cacho J, European journal of clinical investigation . 1999,第7期

机译：阿尔茨海默氏病epsilon 4载脂蛋白E等位基因携带者的血清锌，铜，胰岛素和脂质（请参阅评论）
3. Lipid Alterations in the Earliest Clinically Recognizable Stage of Alzheimer's Disease: Implication of the Role of Lipids in the Pathogenesis of Alzheimer's Disease [J] . Xianlin Han Current Alzheimer Research . 2005,第1期

机译：阿尔茨海默氏病的临床早期识别阶段的脂质改变：脂质在阿尔茨海默氏病发病机理中的作用
4. PROFILING OF MEMBRANE LIPIDS RELEVANT TO ALZHEIMER'S DISEASE PATHOGENESIS [C] . Zdenek Spacil, Eliska Cechova, Petr Telensky, International Mass Spectrometry Conference . 2018

机译：与阿尔茨海默病发病机制相关的膜脂质的分析
5. Serum lipids and statin therapy in relation to Alzheimer's disease: Exploring the relationship between elevated serum cholesterol levels and Alzheimer's disease dementia. [D] . Brinker, Krystin. 2011

机译：与阿尔茨海默氏病有关的血脂和他汀类药物治疗：探讨血清胆固醇水平升高与阿尔茨海默氏病痴呆症之间的关系。
6. Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease [O] . Matthew R Halliday, Sanket V Rege, Qingyi Ma, 2016

机译：载脂蛋白E4携带阿尔茨海默氏病的患者加速周细胞变性和血脑屏障破坏
7. The use of angiotensin-converting enzyme inhibitors vs. angiotensin receptor blockers and cognitive decline in Alzheimer’s disease: the importance of blood-brain barrier penetration and APOE ε4 carrier status [O] . Michael Ouk, Che-Yuan Wu, Jennifer S. Rabin, 2021

机译：Alzheimer疾病中血管紧张素转化酶抑制剂与血管紧张素受体阻滞剂和认知下降的使用：血脑屏障渗透和Apoeε4载体状态的重要性

Lipid carrier breaks barrier in Alzheimer's disease

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