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C. elegans interprets bacterial non-coding RN As to learn pathogenic avoidance

机译：C. elegans将细菌非编码RN解释为学习致病性避免

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摘要

ExposingCaenorhabditis elegansto non-coding small RNAs from pathogenicPseudomonas aeruginosainduces avoidance behaviours in treated worms and their progeny, which reveals howC. elegansdiscriminates between bacterial species in its microbial environment.Caenorhabditis elegansmust distinguish pathogens from nutritious food sources among the many bacteria to which it is exposed in its environment(1). Here we show that a single exposure to purified small RNAs isolated from pathogenicPseudomonas aeruginosa(PA14) is sufficient to induce pathogen avoidance in the treated worms and in four subsequent generations of progeny. The RNA interference (RNAi) and PIWI-interacting RNA (piRNA) pathways, the germline and the ASI neuron are all required for avoidance behaviour induced by bacterial small RNAs, and for the transgenerational inheritance of this behaviour. A singleP. aeruginosanon-coding RNA, P11, is both necessary and sufficient to convey learned avoidance of PA14, and itsC. eleganstarget,maco-1, is required for avoidance. Our results suggest that this non-coding-RNA-dependent mechanism evolved to survey the microbial environment of the worm, use this information to make appropriate behavioural decisions and pass this information on to its progeny.
机译：excainoNorhabditisegaSegansto非编码小RNA来自致病虫病毒毒素的避免行为及其后代，揭示了HOWC。细菌种类在其微生物环境中的elegansdismiminate.Caenorhabditisolismust在其环境中暴露的许多细菌中区分病原体来自营养食物来源（1）。在这里，我们表明，从致病upseudomonas铜绿假单胞菌（PA14）中分离的纯化的小RNA暴露出来足以在处理过的蠕虫中诱导病原体避免，并在后续几代后代。 RNA干扰（RNAi）和PIWI相互作用的RNA（PiRNA）途径，种系和ASI神经元都是为了通过细菌小RNA诱导的避免行为，以及用于这种行为的转基因遗传。单纯。铜绿假单胞菌编码RNA，P11是必要的，并且足以传达避免PA14和ITSC的学习。 Eleganstarget，Maco-1是避免所必需的。我们的研究结果表明，这种非编码RNA依赖机制演变为调查蠕虫的微生物环境，使用这些信息进行适当的行为决策并将这些信息传递给其后代。

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  • 来源
    《Nature》 |2020年第7829期|445-451|共7页
  • 作者

    Kaletsky Rachel; Moore Rebecca S.; Vrla Geoffrey D.; Parsons Lance R.; Gitai Zemer; Murphy Coleen T.;

  • 作者单位

    Princeton Univ Dept Mol Biol Princeton NJ 08544 USA|Princeton Univ LSI Genom Princeton NJ 08544 USA;

    Princeton Univ Dept Mol Biol Princeton NJ 08544 USA;

    Princeton Univ Dept Mol Biol Princeton NJ 08544 USA;

    Princeton Univ LSI Genom Princeton NJ 08544 USA;

    Princeton Univ Dept Mol Biol Princeton NJ 08544 USA;

    Princeton Univ Dept Mol Biol Princeton NJ 08544 USA|Princeton Univ LSI Genom Princeton NJ 08544 USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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