The major genetic risk factor for severe COVID-19 is inherited from Neanderthals

Zeberg Hugo; Paabo Svante

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The major genetic risk factor for severe COVID-19 is inherited from Neanderthals

机译：严重Covid-19的主要遗传危险因素是从Neanderthals继承的

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A recent genetic association study(1) identified a gene cluster on chromosome 3 as a risk locus for respiratory failure after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A separate study (COVID-19 Host Genetics Initiative)(2) comprising 3,199 hospitalized patients with coronavirus disease 2019 (COVID-19) and control individuals showed that this cluster is the major genetic risk factor for severe symptoms after SARS-CoV-2 infection and hospitalization. Here we show that the risk is conferred by a genomic segment of around 50 kilobases in size that is inherited from Neanderthals and is carried by around 50% of people in south Asia and around 16% of people in Europe.

机译：最近的遗传结合研究（1）鉴定了染色体3上的基因簇，作为患有严重急性呼吸综合征冠状病毒2（SARS-COV-2）感染后呼吸衰竭的风险基因座。单独的研究（Covid-19宿主遗传学倡议）（2）包括2019（Covid-19）和对照个体的3,199名住院患者患者（Covid-19）和对照个体表明，该集群是SARS-COV-2感染后严重症状的主要遗传危险因素和住院。在这里，我们表明风险是由尼安德特人继承的大约50千碱基的基因组片段赋予风险，并被南亚的大约50％的人和欧洲占16％的人进行。

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来源
《Nature》 |2020年第7835期|610-612|共3页
作者
Zeberg Hugo; Paabo Svante;
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作者单位

Max Planck Inst Evolutionary Anthropol Leipzig Germany|Karolinska Inst Dept Neurosci Stockholm Sweden;

Max Planck Inst Evolutionary Anthropol Leipzig Germany|Okinawa Inst Sci & Technol Onna Son Japan;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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7. The major genetic risk factor for severe COVID-19 is inherited from Neanderthals [O] . Hugo Zeberg, Svante Pääbo 2020

机译：严重Covid-19的主要遗传危险因素是从Neanderthals继承的

The major genetic risk factor for severe COVID-19 is inherited from Neanderthals

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