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The neuropeptide Pth2 dynamically senses others via mechanosensation

机译：神经肽PTH2通过机动力动态地感测其它

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摘要

Species that depend on membership in social groups for survival exhibit changes in neuronal gene expression and behaviour when they face restricted social interactions or isolation~(1-3). Here we show that, across the lifespan of zebrafish (Danio rerio), social isolation specifically decreased the level of transcription of pth2, the gene that encodes the vertebrate-specific neuropeptide Pth2. However, 30 minutes of exposure to conspecifics was sufficient to initiate a significant rescue of pth2 transcript levels in previously isolated zebrafish. Transcription of pth2 exhibited bidirectional dynamics; following the acute isolation of socially reared fish, a rapid reduction in the levels of pth2 was observed. The expression of pth2 tracked not only the presence of other fish but also the density of the group. The sensory modality that controls the expression of pth2 was neither visual nor chemosensory in origin but instead was mechanical, induced by the movements of neighbouring fish. Chemical ablation of the mechanosensitive neuromast cells within the lateral line of fish prevented the rescue of pth2 levels that was induced by the social environment. In addition, mechanical perturbation of the water at frequencies similar to the movements of the zebrafish tail was sufficient to rescue the levels of pth2 in previously isolated fish. These data indicate a previously underappreciated role for the relatively unexplored neuropeptide Pth2 in both tracking and responding to the population density of the social environment of an animal.
机译：依赖于社会群体的成员的物种在人们面对受限制的社会互动或隔离时表现出神经元基因表达和行为的变化〜（1-3）。在这里，我们表明，在斑马鱼（Danio Rerio）的寿命中，社会隔离明显降低了PTH2的转录水平，该基因编码脊椎动物特异性神经肽PTH2。然而，30分钟的暴露于引发方法足以在前孤立的斑马鱼中启动Pth2转录水平的显着救援。 PTH2的转录表现出双向动力学;在对社会饲养的鱼类的急性隔离之后，观察到PTH2水平的快速降低。 PTH2的表达不仅跟踪了其他鱼的存在，还跟踪了该组的密度。控制PTH2表达的感觉形式既不是视觉也不是邻近的，而是由邻近鱼的运动引起的机械。鱼类横向线内机械敏感性神经孢子细胞的化学消融阻止了社会环境引起的PTH2水平。此外，在类似于斑马鱼尾部的运动的频率下的水机械扰动足以拯救以前分离的鱼中的pth2水平。这些数据表明在追踪和响应动物社会环境的人口密度的跟踪和响应人口密度方面，这些数据表明了相对未探明的神经肽PTH2的作用。

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  • 来源
    《Nature》 |2020年第7839期|653-657|共5页
  • 作者

    Lukas Anneser; Ivan C Alcantara; Anja Gemmer; Kristina Mirkes; Soojin Ryu; Erin M Schuman;

  • 作者单位

    Max Planck Institute for Brain Research;

    Max Planck Institute for Brain Research|Brown University;

    Max Planck Institute for Brain Research;

    Max Planck Institute for Brain Research;

    Johannes Gutenberg University Medical Center|Living Systems Institute College of Medicine and Health University of Exeter;

    Max Planck Institute for Brain Research;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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