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首页> 外文期刊>Nature >Coupling of hippocampal theta and ripples with pontogeniculooccipital waves
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Coupling of hippocampal theta and ripples with pontogeniculooccipital waves

机译：海马θ的偶联和脉络膜胶囊波的涟漪

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摘要

The hippocampus has a major role in encoding and consolidating long-term memories, and undergoes plastic changes during sleep~(1). These changes require precise homeostatic control by subcortical neuromodulatory structures~(2). The underlying mechanisms of this phenomenon, however, remain unknown. Here, using multi-structure recordings in macaque monkeys, we show that the brainstem transiently modulates hippocampal network events through phasic pontine waves known as pontogeniculooccipital waves (PGO waves). Two physiologically distinct types of PGO wave appear to occur sequentially, selectively influencing high-frequency ripples and low-frequency theta events, respectively. The two types of PGO wave are associated with opposite hippocampal spike-field coupling, prompting periods of high neural synchrony of neural populations during periods of ripple and theta instances. The coupling between PGO waves and ripples, classically associated with distinct sleep stages, supports the notion that a global coordination mechanism of hippocampal sleep dynamics by cholinergic pontine transients may promote systems and synaptic memory consolidation as well as synaptic homeostasis.
机译：海马在编码和整合长期记忆中具有重要作用，并在睡眠期间进行塑性变化〜（1）。这些变化需要通过皮下神经调节结构精确稳态对照〜（2）。然而，这种现象的潜在机制仍然是未知的。在这里，在猕猴中使用多结构录制，我们表明脑干过度调节通过称为枢塞菌皮波（PGO波）的常相毒素波来调节海马网络事件。两种生理上不同类型的PGO波似乎依次发生，选择性地影响高频涟漪和低频θ事件。两种类型的PGO波与对相对的海马峰值峰场耦合，在纹波和θ的情况下，神经群的高神经血管同步的升序周期。 PGO波和涟漪之间的耦合，经典与不同的睡眠阶段相关联，支持胆碱能猪瞬变的海马睡眠动力学的全局协调机制可以促进系统和突触记忆合并以及突触稳态。

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  • 来源
    《Nature》 |2021年第7840期|96-102|共7页
  • 作者

    Juan F Ramirez-Villegas; Michel Besserve; Yusuke Murayama; Henry C Evrard; Axel Oeltermann; Nikos K Logothetis;

  • 作者单位

    Department of Physiology of Cognitive Processes Max Planck Institute for Biological Cybernetics|Graduate School of Neural and Behavioral Sciences International Max Planck Research School Eberhard-Karls University of Tübingen|IST Austria (Institute of Science and Technology Austria);

    Department of Physiology of Cognitive Processes Max Planck Institute for Biological Cybernetics|Department of Empirical Inference Max Planck Institute for Intelligent Systems;

    Department of Physiology of Cognitive Processes Max Planck Institute for Biological Cybernetics|International Center for Primate Brain Research;

    Department of Physiology of Cognitive Processes Max Planck Institute for Biological Cybernetics|International Center for Primate Brain Research|Werner-Reichardt Centre for Integrative Neuroscience|Nathan Kline Institute for Psychiatric Research;

    Department of Physiology of Cognitive Processes Max Planck Institute for Biological Cybernetics;

    Department of Physiology of Cognitive Processes Max Planck Institute for Biological Cybernetics|International Center for Primate Brain Research|Centre for Imaging Sciences Biomedical Imaging Institute The University of Manchester;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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