• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature >PIEZO2 in sensory neurons and urothelial cells coordinates urination
【24h】

PIEZO2 in sensory neurons and urothelial cells coordinates urination

机译：在感觉神经元和尿路上细胞中的Piezo2坐标排尿

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

PIEZO2 is expressed in the bladder urothelium and sensory neurons innervating the lower urinary tract and is a key mechanosensor for the control of urination.Henry Miller stated that "to relieve a full bladder is one of the great human joys". Urination is critically important in health and ailments of the lower urinary tract cause high pathological burden. Although there have been advances in understanding the central circuitry in the brain that facilitates urination(1-3), there is a lack of in-depth mechanistic insight into the process. In addition to central control, micturition reflexes that govern urination are all initiated by peripheral mechanical stimuli such as bladder stretch and urethral flow(4). The mechanotransduction molecules and cell types that function as the primary stretch and pressure detectors in the urinary tract mostly remain unknown. Here we identify expression of the mechanosensitive ion channel PIEZO2 in lower urinary tract tissues, where it is required for low-threshold bladder-stretch sensing and urethral micturition reflexes. We show that PIEZO2 acts as a sensor in both the bladder urothelium and innervating sensory neurons. Humans and mice lacking functional PIEZO2 have impaired bladder control, and humans lacking functional PIEZO2 report deficient bladder-filling sensation. This study identifies PIEZO2 as a key mechanosensor in urinary function. These findings set the foundation for future work to identify the interactions between urothelial cells and sensory neurons that control urination.
机译：Piezo2在膀胱尿路鞘细胞和感觉神经元中表示，负责下尿路，是控制排尿的关键机械传感器.Henry Miller表示“缓解全膀胱是伟大的人类娱乐之一”。排尿对泌尿道的健康和疾病是重要的，导致病态负担高。尽管在促进排尿中的大脑中理解中央电路（1-3），但是缺乏深入的机械洞察力的进步。除了中央控制之外，控制排尿的喷射反射都是通过外围机械刺激引发的，例如膀胱拉伸和尿道流（4）。用作泌尿道中的主要拉伸和压力探测器的机械手机和细胞类型主要仍然未知。这里我们鉴定了低尿路组织中机械敏感离子通道压电2的表达，在那里需要低阈值膀胱拉伸感测和尿道喷射反射。我们表明，压电2用作膀胱尿路升管和接管感觉神经元中的传感器。缺乏功能性压电2的人和小鼠有膀胱控制受损，人类缺乏功能性压电2报告缺乏膀胱填充感。本研究将压电2识别为泌尿功能中的关键机械传感器。这些调查结果为将来的工作设定了基础，以鉴定控制排尿的尿液细胞和感官神经元之间的相互作用。

著录项

  • 来源
    《Nature》 |2020年第7837期|290-295|共6页
  • 作者

    Marshall Kara L.; Saade Dimah; Ghitani Nima; Coombs Adam M.; Szczot Marcin; Keller Jason; Ogata Tracy; Daou Ihab; Stowers Lisa T.; Bonnemann Carsten G.; Chesler Alexander T.; Patapoutian Ardem;

  • 作者单位

    Scripps Res Inst Howard Hughes Med Inst Dept Neurosci Dorris Neurosci Ctr La Jolla CA 92037 USA;

    NINDS NIH Bldg 36 Rm 4D04 Bethesda MD 20892 USA;

    NIH Natl Ctr Complementary & Integrat Hlth Bldg 10 Bethesda MD 20892 USA;

    Scripps Res Inst Howard Hughes Med Inst Dept Neurosci Dorris Neurosci Ctr La Jolla CA 92037 USA;

    NIH Natl Ctr Complementary & Integrat Hlth Bldg 10 Bethesda MD 20892 USA;

    Scripps Res Inst Dept Neurosci Dorris Neurosci Ctr La Jolla CA 92037 USA|Howard Hughes Med Inst Janelia Res Campus Ashburn VA USA;

    NINDS NIH Bldg 36 Rm 4D04 Bethesda MD 20892 USA;

    Scripps Res Inst Howard Hughes Med Inst Dept Neurosci Dorris Neurosci Ctr La Jolla CA 92037 USA;

    Scripps Res Inst Dept Neurosci Dorris Neurosci Ctr La Jolla CA 92037 USA;

    NINDS NIH Bldg 36 Rm 4D04 Bethesda MD 20892 USA;

    NINDS NIH Bldg 36 Rm 4D04 Bethesda MD 20892 USA|NIH Natl Ctr Complementary & Integrat Hlth Bldg 10 Bethesda MD 20892 USA;

    Scripps Res Inst Howard Hughes Med Inst Dept Neurosci Dorris Neurosci Ctr La Jolla CA 92037 USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号