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Neural circuit mechanisms of sexual receptivity in Drosophila females

机译:果蝇女性性接受性的神经回路机制

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摘要

Choosing a mate is one of the most consequential decisions a female will make during her lifetime. A female fly signals her willingness to mate by opening her vaginal plates, allowing a courting male to copulate(1,2). Vaginal plate opening (VPO) occurs in response to the male courtship song and is dependent on the mating status of the female. How these exteroceptive (song) and interoceptive (mating status) inputs are integrated to regulate VPO remains unknown. Here we characterize the neural circuitry that implements mating decisions in the brain of female Drosophila melanogaster. We show that VPO is controlled by a pair of female-specific descending neurons (vpoDNs). The vpoDNs receive excitatory input from auditory neurons (vpoENs), which are tuned to specific features of the D. melanogaster song, and from pC1 neurons, which encode the mating status of the female(3,4). The song responses of vpoDNs, but not vpoENs, are attenuated upon mating, accounting for the reduced receptivity of mated females. This modulation is mediated by pC1 neurons. The vpoDNs thus directly integrate the external and internal signals that control the mating decisions of Drosophila females.
机译:选择伴侣是女性在她一生中的最重要决定之一。一只女性通过打开阴道板来表示她愿意伴侣,让雄心男性交联(1,2)。阴道板开口(VPO)响应男性求爱歌曲,依赖于女性的交配状态。这些遗产(歌曲)和Interoceptive(交配状态)输入如何集成以调节VPO仍然未知。在这里,我们的特征在于在雌性果蝇黑素体的大脑中实现交配决策的神经电路。我们表明VPO由一对母特异性下行神经元(VPODN)控制。 VPODN接受来自听觉神经元(VPoens)的兴奋性输入,这些输入被调整为D. melanogaster歌曲的特定特征,以及从PC1神经元编码女性(3,4)的配合状态。在交配时,VPODNS但不是VPONE的歌曲响应,占据了交配女性的减少的接受性。该调制由PC1神经元介导。因此,VPODN直接整合控制果蝇女性的交配决定的外部和内部信号。

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  • 来源
    《Nature》 |2021年第7843期|577-581|共5页
  • 作者单位

    Howard Hughes Med Inst Janelia Res Campus Ashburn VA 20147 USA;

    Howard Hughes Med Inst Janelia Res Campus Ashburn VA 20147 USA;

    Howard Hughes Med Inst Janelia Res Campus Ashburn VA 20147 USA;

    Howard Hughes Med Inst Janelia Res Campus Ashburn VA 20147 USA;

    Howard Hughes Med Inst Janelia Res Campus Ashburn VA 20147 USA;

    Howard Hughes Med Inst Janelia Res Campus Ashburn VA 20147 USA;

    Howard Hughes Med Inst Janelia Res Campus Ashburn VA 20147 USA|Univ Queensland Queensland Brain Inst St Lucia Qld Australia;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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