• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature >SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans
【24h】

SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans

机译：SARS-COV-2感染诱导人类的长期骨髓血浆细胞

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Long-lived bone marrow plasma cells (BMPCs) are a persistent and essential source of protective antibodies~(1-7). Individuals who have recovered from COVID-19 have a substantially lower risk of reinfection with SARS-CoV-2~(8-10). Nonetheless, it has been reported that levels of anti-SARS-CoV-2 serum antibodies decrease rapidly in the first few months after infection, raising concerns that long-lived BMPCs may not be generated and humoral immunity against SARS-CoV-2 may be short-lived~(11-13). Here we show that in convalescent individuals who had experienced mild SARS-CoV-2 infections (n = 77), levels of serum anti-SARS-CoV-2 spike protein (S) antibodies declined rapidly in the first 4 months after infection and then more gradually over the following 7 months, remaining detectable at least 11 months after infection. Anti-S antibody titres correlated with the frequency of S-specific plasma cells in bone marrow aspirates from 18 individuals who had recovered from COVID-19 at 7 to 8 months after infection. S-specific BMPCs were not detected in aspirates from 11 healthy individuals with no history of SARS-CoV-2 infection. We show that S-binding BMPCs are quiescent, which suggests that they are part of a stable compartment. Consistently, circulating resting memory B cells directed against SARS-CoV-2 S were detected in the convalescent individuals. Overall, our results indicate that mild infection with SARS-CoV-2 induces robust antigen-specific, long-lived humoral immune memory in humans.
机译：长寿的骨髓血浆细胞（BMPC）是保护抗体的持续和必要的源〜（1-7）。从Covid-19中恢复的个体具有与SARS-COV-2〜（8-10）的重新凝聚的风险显着降低。尽管如此，据报道，抗SARS-COV-2血清抗体的水平在感染后的前几个月迅速下降，提高了令人担忧的是，可能不会产生长寿命的BMPC和针对SARS-COV-2的体液免疫力短期〜（11-13）。在这里，我们显示，在患有轻度SARS-COV-2感染的康复人员（n = 77）中，血清抗SARS-COV-2刺蛋白蛋白的水平在感染后的前4个月内迅速下降，然后在接下来的7个月内逐渐逐渐，感染后至少11个月剩余可检测。与感染后7至8个月的18个个体，与18个骨髓吸气中的S特异性血浆细胞的抗体滴度相关的抗体滴度与感染后7至8个月。在11个健康个体中未检测到S特异性BMPCs，没有SARS-COV-2感染病史。我们表明S绑定BMPC是静止的，这表明它们是稳定隔间的一部分。始终如一地，在康复个体中检测到针对SARS-COV-2S的循环休息记忆B细胞。总体而言，我们的结果表明，SARS-COV-2的温和感染诱导人类中的强大的抗原特异性长期的体液免疫记忆。

著录项

  • 来源
    《Nature》 |2021年第7867期|421-425|共5页
  • 作者

    Jackson S Turner; Wooseob Kim; Elizaveta Kalaidina; Charles W Goss; Adriana M Rauseo; Aaron J Schmitz; Lena Hansen; Alem Haile; Michael K Klebert; Iskra Pusic; Jane A OHalloran; Rachel M Presti; Ali H Ellebedy;

  • 作者单位

    Department of Pathology and Immunology Washington University School of Medicine;

    Department of Pathology and Immunology Washington University School of Medicine;

    Division of Allergy and Immunology Department of Internal Medicine Washington University School of Medicine;

    Division of Biostatistics Washington University School of Medicine;

    Division of Infectious Diseases Department of lnternal Medicine Washington University School of Medicine;

    Department of Pathology and Immunology Washington University School of Medicine;

    Department of Pathology and Immunology Washington University School of Medicine|Influenza Centre Department of Clinical Science University of Bergen;

    Clinical Trials Unit Washington University School of Medicine;

    Clinical Trials Unit Washington University School of Medicine;

    Division of Oncology Department of Internal Medicine Washington University School of Medicine;

    Division of Infectious Diseases Department of lnternal Medicine Washington University School of Medicine;

    Division of Infectious Diseases Department of lnternal Medicine Washington University School of Medicine|Center for Vaccines and Immunity to Microbial Pathogens Washington University School of Medicine;

    Department of Pathology and Immunology Washington University School of Medicine|Center for Vaccines and Immunity to Microbial Pathogens Washington University School of Medicine|The Andrew M. and Jane M. Bursky Center for Human Immunology & Immunotherapy Programs Washington University School of Medicine;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号