TMK-based cell-surface auxin signalling activates cell-wall acidification

Lin Wenwei; Zhou Xiang; Tang Wenxin; Takahashi Koji; Pan Xue; Dai Jiawei; Ren Hong; Zhu Xiaoyue; Pan Songqin; Zheng Haiyan; Gray William M.; Xu Tongda; Kinoshita Toshinori; Yang Zhenbiao

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TMK-based cell-surface auxin signalling activates cell-wall acidification

机译：基于TMK的细胞 - 表面助线信号传导激活细胞壁酸化

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The phytohormone auxin controls many processes in plants, at least in part through its regulation of cell expansion(1). The acid growth hypothesis has been proposed to explain auxin-stimulated cell expansion for five decades, but the mechanism that underlies auxin-induced cell-wall acidification is poorly characterized. Auxin induces the phosphorylation and activation of the plasma membrane H+-ATPase that pumps protons into the apoplast(2), yet how auxin activates its phosphorylation remains unclear. Here we show that the transmembrane kinase (TMK) auxin-signalling proteins interact with plasma membrane H+-ATPases, inducing their phosphorylation, and thereby promoting cell-wall acidification and hypocotyl cell elongation in Arabidopsis. Auxin induced interactions between TMKs and H+-ATPases in the plasma membrane within seconds, as well as TMK-dependent phosphorylation of the penultimate threonine residue on the H+-ATPases. Our genetic, biochemical and molecular evidence demonstrates that TMKs directly phosphorylate plasma membrane H+-ATPase and are required for auxin-induced H+-ATPase activation, apoplastic acidification and cell expansion. Thus, our findings reveal a crucial connection between auxin and plasma membrane H+-ATPase activation in regulating apoplastic pH changes and cell expansion through TMK-based cell surface auxin signalling.

机译：植物甾族植物毒素至少通过其调节细胞膨胀（1）来控制植物中的许多过程。已经提出了酸生长假设，以解释毒素刺激的细胞扩张五十年，但是潜在诱导的细胞壁酸化的机制表征差。蟾蜍蛋白诱导磷酸化和活化的血浆膜H + -ATP酶的磷酸化和活化，其将质子泵入Apoplast（2），然而如何激活其磷酸化仍然不清楚。在这里，我们表明跨膜激酶（TMK）毒素信号传导蛋白与血浆膜H + -ATP酶相互作用，诱导其磷酸化，从而促进拟南芥中的细胞壁酸化和缺口细胞伸长率。在几秒钟内，血管膜中TMK和H + -ATP酶与H + -ATP酶之间的相互作用，以及在H + -ATP酶上的倒数二苏氨酸残基的TMK依赖性磷酸化。我们的遗传学，生化和分子证据表明，TMKs直接磷酸化血浆膜H + -ATP酶，并且需要用于肿瘤诱导的H + -ATP酶活化，妊娠酸化和细胞膨胀所需的。因此，我们的研究结果揭示了通过TMK基细胞表面寰骨信号传导调节静脉曲张塑料pH变化和细胞膨胀在调节妊娠pH变化和细胞膨胀之间的关键联系。

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《Nature》 |2021年第7884期|278-282|共5页
作者
Lin Wenwei; Zhou Xiang; Tang Wenxin; Takahashi Koji; Pan Xue; Dai Jiawei; Ren Hong; Zhu Xiaoyue; Pan Songqin; Zheng Haiyan; Gray William M.; Xu Tongda; Kinoshita Toshinori; Yang Zhenbiao;
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作者单位

Fujian Agr & Forestry Univ FAFU UCR Joint Ctr Hort Biol & Metabol Haixia Inst Sci & Technol Fuzhou Peoples R China|Univ Calif Riverside Inst Integrat Genome Biol Riverside CA 92521 USA|Univ Calif Riverside Dept Bot & Plant Sci Riverside CA 92521 USA;

Fujian Agr & Forestry Univ FAFU UCR Joint Ctr Hort Biol & Metabol Haixia Inst Sci & Technol Fuzhou Peoples R China|Univ Calif Riverside Inst Integrat Genome Biol Riverside CA 92521 USA|Univ Calif Riverside Dept Bot & Plant Sci Riverside CA 92521 USA;

Fujian Agr & Forestry Univ FAFU UCR Joint Ctr Hort Biol & Metabol Haixia Inst Sci & Technol Fuzhou Peoples R China;

Nagoya Univ Grad Sch Sci Nagoya Aichi Japan|Nagoya Univ Inst Transformat Biomol Nagoya Aichi Japan;

Univ Calif Riverside Inst Integrat Genome Biol Riverside CA 92521 USA|Univ Calif Riverside Dept Bot & Plant Sci Riverside CA 92521 USA;

Fujian Agr & Forestry Univ FAFU UCR Joint Ctr Hort Biol & Metabol Haixia Inst Sci & Technol Fuzhou Peoples R China;

Univ Minnesota Dept Plant & Microbial Biol St Paul MN 55108 USA;

Fujian Agr & Forestry Univ FAFU UCR Joint Ctr Hort Biol & Metabol Haixia Inst Sci & Technol Fuzhou Peoples R China;

Univ Calif Riverside Inst Integrat Genome Biol Riverside CA 92521 USA|Univ Calif Riverside Dept Bot & Plant Sci Riverside CA 92521 USA;

Robert Wood Johnson Med Sch Biol Mass Spectrometry Facil Piscataway NJ USA|Rutgers State Univ Piscataway NJ USA;

Univ Minnesota Dept Plant & Microbial Biol St Paul MN 55108 USA;

Fujian Agr & Forestry Univ FAFU UCR Joint Ctr Hort Biol & Metabol Haixia Inst Sci & Technol Fuzhou Peoples R China;

Nagoya Univ Grad Sch Sci Nagoya Aichi Japan|Nagoya Univ Inst Transformat Biomol Nagoya Aichi Japan;

Fujian Agr & Forestry Univ FAFU UCR Joint Ctr Hort Biol & Metabol Haixia Inst Sci & Technol Fuzhou Peoples R China|Univ Calif Riverside Inst Integrat Genome Biol Riverside CA 92521 USA|Univ Calif Riverside Dept Bot & Plant Sci Riverside CA 92521 USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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1. Endosomal acidification by Na~+/H~+ exchanger NHE5 regulates TrkA cell-surface targeting and NGF-induced PI3K signaling [J] . Graham H. Diering, Yuka Numata, Steven Fan, Molecular biology of the cell . 2013,第21期

机译：Na〜+ / H〜+交换子NHE5的内体酸化调节TrkA细胞表面靶向和NGF诱导的PI3K信号传导
2. Endosomal acidification by Na+/H+ exchanger NHE5 regulates TrkA cell-surface targeting and NGF-induced PI3K signaling [J] . Graham H. Diering, Yuka Numata, Steven Fan, Molecular biology of the cell . 2013,第21期

机译：Na + / H +交换子NHE5的内体酸化调节TrkA细胞表面靶向和NGF诱导的PI3K信号传导
3. Mitogen Activated Protein Kinase (MPK) Interacts With Auxin Influx Carrier (OsAux/LAX1) Involved in Auxin Signaling in Plant [J] . Tapan Kumar Mohanta, Nibedita Mohanta, Pratap Parida, Biological Procedures Online . 2015,第1期

机译：丝裂原激活的蛋白激酶（MPK）与植物生长素信号转导的生长素流入载体（OsAux / LAX1）相互作用。
4. Static magnetic field regulates Arabidopsis root growth via auxin signaling [C] . Yue Jin, Wei Guo, Xupeng Hu, The 8th International Conference on Magneto- Science（第八届国际磁科学会议）论文集 . -1

机译：静态磁场通过养蛋白信号调节拟南芥根系生长
5. Auxin signal transduction through mitogen-activated protein kinase (MAPK) in roots of Arabidopsis thaliana. [D] . Mockaitis, Keithanne. 2000

机译：通过拟南芥根中有丝分裂原激活的蛋白激酶（MAPK）的生长素信号转导。
6. Endosomal acidification by Na+/H+ exchanger NHE5 regulates TrkA cell-surface targeting and NGF-induced PI3K signaling [O] . Graham H. Diering, Yuka Numata, Steven Fan, 2013

机译：Na + / H +交换子NHE5的内体酸化调节TrkA细胞表面靶向和NGF诱导的PI3K信号传导
7. TMK-based cell surface auxin signaling activates cell wall acidification in Arabidopsis [O] . Zhenbiao Yang, Wenwei Lin, Wenxin Tang, 2021

机译：基于TMK的细胞表面植物素信号传导在拟南芥中激活细胞壁酸化
8. Valency of CD3 Binding and Internalization of the CD3 Cell-Surface Complex Control T Cell Responses to Second Signals: Distinction between Effects on Protein in Kinase C, Cytoplasmic Free Calcium, and Proliferation [R] . Ledbetter, J. A., June, C. H., Martin, P. J., 1986

机译：CD3结合和内化CD3细胞表面复合物对照T细胞对第二信号的反应的价值：激酶C中蛋白质，细胞质游离钙和增殖之间的区别

TMK-based cell-surface auxin signalling activates cell-wall acidification

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