Space is set to be the next frontier in cell-cycle research. Until now, the focus has been on how the cell cycle is regulated in time, by the synthesis and destruction of regulatory proteins such as the cyclins. But this is a one-dimensional view, and there is increasing evidence that the cell cycle is controlled by localizing specific regulators to the right place at the right time. An example of this is reported by Paul Russell and colleagues on page 172 of this issue. They show that, in the fission yeast Schizosaccharomyces pombe, the Cdc25 phosphatase — an essential regulator of mitosis — is exported from the nucleus in response to DNA damage. Export separates Cdc25 from its substrate, the cyclin B/Cdc2 kinase, thereby stopping cells from entering mitosis. Moreover, Cdc25 is exported from the nucleus by association with a protein called Rad24, which acts as an attachable nuclear-export sequence.
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机译：太空将成为细胞周期研究的下一个前沿领域。到目前为止，焦点一直集中在如何通过合成和破坏调节蛋白（例如细胞周期蛋白）来及时调节细胞周期。但这是一维的观点，越来越多的证据表明，通过在合适的时间将特定的调节子定位在合适的位置来控制细胞周期。 Paul Russell及其同事在本期第172页上报道了一个这样的例子。他们表明，裂变酵母粟酒裂殖酵母中，Cdc25磷酸酶（一种有丝分裂的重要调节剂）响应DNA损伤而从细胞核中输出。 Export将Cdc25从其底物细胞周期蛋白B / Cdc2激酶中分离出来，从而阻止细胞进入有丝分裂状态。此外，Cdc25通过与称为Rad24的蛋白质结合而从核中输出，该蛋白质充当可附着的核输出序列。
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