Capping off the ends

Carolyn Price

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Capping off the ends

机译：结束两端

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How many times have you had to deal with a loose end? Whether it be a stray end of hair, a frayed end of rope or the exposed end of a chromosome, ends can pose a problem. Reporting in Cell, Steve Schultz and co-workers describe how the ciliate Oxytricha nova deals with the ends of its chromosomal DNA (telomeres). They have solved the crystal structure of the telomere end-binding protein (TEBP), which forms a protective cap over the DNA terminus. Their structure illustrates how the TEBP is exquisitely tailored to solve the chromosome-end problem, and also provides insights into how single-stranded (ss) DNA-binding proteins can recognize a particular sequence.

机译：您不得不处理几次松散的结局？不管是头发的散乱末端，绳子的磨损末端还是染色体的裸露末端，都会造成问题。史蒂夫·舒尔茨（Steve Schultz）及其同事在《细胞》杂志上的报道描述了纤毛虫Oxytricha nova如何处理其染色体DNA（端粒）的末端。他们解决了端粒末端结合蛋白（TEBP）的晶体结构，该结构在DNA末端形成了保护帽。它们的结构说明了如何精制TEBP以解决染色体末端问题，并且还提供了有关单链（ss）DNA结合蛋白如何识别特定序列的见解。

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《Nature》 |1999年第6716期|p.213-214|共2页
作者
Carolyn Price;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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