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A reversibly antigen-responsive hydrogel

机译：可逆的抗原反应水凝胶

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摘要

Stimuli-responsive hydrogels that undergo abrupt changes in volume in response to external stimuli such as pH, temperature and solvent composition have potential applications in biomedi-cine and the creation of 'intelligent' materials systems, for example as media for drug delivery, separation processes and protein immobilization. Hydrogels have been reported that respond to pH, temperature, electric fields and saccharides. For some biomedical applications it would be very useful to have a material whose swelling response was dictated by a specific protein. Here we report such a material, which swells reversibly in a buffer solution in response to a specific antigen. The hydrogel was prepared by grafting the antigen and corresponding antibody to the polymer network, so that binding between the two introduces crosslinks in the network. Competitive binding of the free antigen triggers a change in gel volume owing to breaking of these non-covalent crosslinks. In addition, we show that the hydrogel displays shape-memory behaviour, and that stepwise changes in antigen concentration can induce pulsatile permeation of a protein through the network.
机译：响应于外部刺激（例如pH值，温度和溶剂组成）而发生体积突然变化的刺激响应水凝胶在生物医学和“智能”材料系统的创建中具有潜在的应用，例如作为药物输送，分离过程的介质和蛋白质固定化。据报道，水凝胶对pH，温度，电场和糖有反应。对于某些生物医学应用，具有其膨胀反应由特定蛋白质决定的材料将非常有用。在这里，我们报道了这样一种材料，该材料可响应特定抗原在缓冲溶液中可逆溶胀。通过将抗原和相应的抗体嫁接到聚合物网络中来制备水凝胶，以使两者之间的结合在网络中引入交联。游离抗原的竞争性结合由于这些非共价交联的断裂而触发了凝胶体积的变化。此外，我们表明水凝胶显示出形状记忆行为，并且抗原浓度的逐步变化可以诱导蛋白质通过网络的脉动渗透。

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