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Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction.

机译:Dickkopf-1是分泌蛋白新家族的成员,并在头部诱导中起作用。

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摘要

The Spemann organizer in amphibian embryos is a tissue with potent head-inducing activity, the molecular nature of which is unresolved. Here we describe dickkopf-1 (dkk-1), which encodes Dkk-1, a secreted inducer of Spemann's organizer in Xenopus and a member of a new protein family. Injections of mRNA and antibody indicate that dkk-1 is sufficient and necessary to cause head induction. dkk-1 s a potent antagonist of Wnt signalling, suggesting that dkk genes encode a family of secreted Wnt inhibitors.
机译:两栖动物胚胎中的Spemann组织者是一种具有强大的诱导头活性的组织,其分子性质尚未解决。在这里,我们描述了dickkopf-1(dkk-1),它编码Dkk-1,它是非洲爪蟾中Spemann组织者的分泌诱导物,是新蛋白家族的成员。注射mRNA和抗体表明dkk-1足以引起头诱导。 dkk-1是Wnt信号的有效拮抗剂,表明dkk基因编码一个分泌型Wnt抑制剂家族。

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