Spatiotemporal evolution of ventricular fibrillation

Francis X. Witkowski; L. Joshua Leon; Patricia A. Penkoske; Wayne R. Giles; Mark L. Spano; William L. Ditto; Arthur T. Winfree

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Spatiotemporal evolution of ventricular fibrillation

机译：心室纤颤的时空演变

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摘要

Sudden cardiac death is the leading cause of death in the industrialized world, with the majority of such tragedies being due to ventricular fibrillation. Ventricular fibrillation is a frenzied and irregular disturbance of the heart rhythm that quickly renders the heart incapable of sustaining life. Rotors, electrophysiological structures that emit rotating spiral waves, occur in several systems that all share with the heart the functional properties of excitability and refractoriness. These re-entrant waves, seen in numerical solutions of simplified models of cardiac tissue, may occur during ventricular tachycardias. It has been difficult to detect such forms of re-entry in fibrillating mammalian ventricles. Here we show that, in isolated perfused dog hearts, high spatial and temporal resolution mapping of optical transmembrane potentials can easily detect transiently erupting rotors during the early phase of ventricular fibrillation. This activity is characterized by a relatively high spatiotemporal cross-correlation. During this early fibrillatory interval, frequent wavefront collisions and wavebreak generation are also dominant features. Interestingly, this spatiotemporal pattern undergoes an evolution to a less highly spatially correlated mechanism that lacks the epicardial manifestations of rotors despite continued myocardial perfusion.

机译：在工业化的世界中，突发性心源性死亡是主要的死亡原因，大多数此类悲剧是由于心室纤颤引起的。心室颤动是对心律的狂热和不规则紊乱，迅速使心脏无法维持生命。转子，发出旋转螺旋波的电生理结构，出现在几个与心脏共享兴奋性和难治性功能特性的系统中。在简化的心脏组织模型的数值解中看到的这些折返波可能发生在室性心动过速期间。很难在纤颤的哺乳动物脑室中检测到这种形式的再进入。在这里，我们表明，在孤立的灌流狗心脏中，光学跨膜电位的高时空分辨率映射可以轻松检测到心室纤颤早期的瞬时爆发转子。这种活动的特点是时空互相关较高。在此早期的颤动间隔期间，频繁的波前碰撞和波浪破裂的产生也是主要特征。有趣的是，这种时空模式经历了向空间相关程度较低的机制的演变，尽管持续进行了心肌灌注，但该机制缺乏转子的心外膜表现。

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来源
《Nature》 |1998年第6671期|p.78-82|共5页
作者
Francis X. Witkowski; L. Joshua Leon; Patricia A. Penkoske; Wayne R. Giles; Mark L. Spano; William L. Ditto; Arthur T. Winfree;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. The effects of remodeling with heart failure on mode of initiation of ventricular fibrillation and its spatiotemporal organization [J] . Everett Thomas H., Hulley George S., Lee Ken W., Journal of interventional cardiac electrophysiology: an international journal of arrhythmias and pacing . 2015,第3期

机译：心力衰竭重塑对心室纤颤起始方式及其时空组织的影响
2. The effects of remodeling with heart failure on mode of initiation of ventricular fibrillation and its spatiotemporal organization [J] . Everett Thomas H., Hulley George S., Lee Ken W., Journal of interventional cardiac electrophysiology: an international journal of arrhythmias and pacing . 2015,第3期

机译：心力衰竭重塑对心室颤动的起始模式及其起动性组织的影响
3. Spatiotemporal correlation between phase singularities and wavebreaks during ventricular fibrillation. [J] . Liu YB, Peter A, Lamp ST, Journal of cardiovascular electrophysiology . 2003,第10期

机译：心室纤颤期间相位奇异性与波浪之间的时空相关性。
4. Non-invasive assessment of spatiotemporal organization of ventricular fibrillation through principal component analysis [C] . Marianna Meo, Mark Potse, Stéphane Puyo, Computing in Cardiology Conference . 2017

机译：通过主成分分析非侵入性评估室颤的时空组织
5. Spatiotemporal dynamics of ventricular fibrillation in a three-dimensional anisotropic heart model. [D] . Fitz-Clarke, John Robert. 2003

机译：三维各向异性心脏模型中室颤的时空动态。
6. Insights Into the Spatiotemporal Patterns of Complexity of Ventricular Fibrillation by Multilead Analysis of Body Surface Potential Maps [O] . Marianna Meo, Arnaud Denis, Frédéric Sacher, 2020

机译：体面潜在地图多地分析对心室颤动的复杂性的空白洞察力洞察
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Spatiotemporal evolution of ventricular fibrillation

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