Substance P equals pain substance?

Leslie Iversen

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Substance P equals pain substance?

机译：P物质等于疼痛物质吗？

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Since von Euler and Gaddum first described substance P (SP) more than 60 years ago, much evidence has accumulated to suggest that this undeca-peptide is released from the terminals of certain sensory nerves, as a chemical neuro-transmitter or modulator. The sensory function of SP is thought, from more circumstantial evidence, to be related to the transmission of pain information into the central nervous system (CNS). This idea is now supported by two studies reported by Cao et al.4 and De Felipe et al.5 on pages 390 and 394, respectively, of this issue. Both groups find that when the function of SP is genetically disrupted in mice, the animals show reduced responses to painful stimuli.

机译：自von Euler和Gaddum于60年前首次描述物质P（SP）以来，已有大量证据表明该十一肽是从某些感觉神经的末端释放的，是一种化学神经递质或调节剂。从更多的间接证据来看，SP的感觉功能被认为与疼痛信息传递到中枢神经系统（CNS）有关。 Cao等人4和De Felipe等人5分别在本期杂志的第390页和第394页报道了两项研究，这一观点现在得到了支持。两组都发现，当SP的功能在小鼠中被遗传破坏时，这些动物对疼痛刺激的反应减弱。

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来源
《Nature》 |1998年第6674期|p.334-335|共2页
作者
Leslie Iversen;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Letter to the Editor: Substance use disorder?Substance-induced disorder clinics for pain-medication addictions and addicted patients' pains: futuristic need for pain physicians sub-specializing in addiction-medicine. [J] . Deepak Gupta, Shushovan Chakrabortty Journal of opioid management . 2018,第1期

机译：致编辑的信：物质使用障碍？物质诱导的疼痛药物成瘾疾病诊所和上瘾的患者痛苦：未来派治疗疼痛医生患上成瘾医学的患者。
2. Chronic Pain Patients Have Greater Rates of Substance Use, Family Substance Use History, and History of Childhood Sexual Abuse When Compared to Psychiatric Controls: A Case-Control Analysis [J] . The American journal on addictions / . 2020,第3期

机译：与精神病毒控制相比，慢性疼痛患者有更高的物质使用，家庭物质使用历史和儿童时期性虐待史的历史：案例控制分析
3. Pain moderates changes in psychological flexibility but not substance use symptoms during substance use disorder treatment [J] . Foster Katherine T., Ehrnstrom Colleen, Cherrnack Stephen, Psychiatry research . 2016,第Null期

机译：疼痛缓解了药物滥用障碍治疗期间的心理柔韧性变化，但没有缓解药物滥用症状
4. Agency for Toxic Substances and Disease Registry’s (ATSDR) Hazardous Substances Emergency Events Surveillance (HSEES) System, National Toxic Substance Incidents Program (NTSIP) 2005-2011 [C] . Natalia Melnikova, Maureen Orr International Symposium on Mary Kay O Connor Process Safety Center . 2013

机译：有毒物质和疾病登记处的机构（ATSDR）危险物质应急事件监测（HSEES）系统，国家有毒物质事件计划（NTSIP）2005-2011
5. Estradiol, Substance P, and the PI3K-Akt-mTOR Pathway in the Dorsal Horn of the Spinal Cord during Inflammatory Pain. [D] . Ferguson, Zane. 2017

机译：炎性疼痛期间脊髓背角中的雌二醇，P物质和PI3K-Akt-mTOR途径。
6. Pain moderates changes in psychological flexibility but not substance use symptoms during substance use disorder treatment [O] . Katherine T. Foster, Colleen Ehrnstrom, Stephen Chermack, -1

机译：疼痛缓解了药物使用障碍治疗期间的心理柔韧性变化但没有缓解药物使用症状
7. Management of disposable substance inventory in Dental Faculty of Jember University still remained any constraints in each management level. Its caused by the lack of controlling of disposable substance under ABC analysis method. Theres no recording approach yet for disposable substance availability which was returned from clinic, cant display yet the stock data in any kind of time, the restoring was not arrange yet by location and substances characteristic, doesnt apply both FEFO ( First Expiry First Out ) and FIFO ( First In First Out ). With ABC analysis, FEFO and FIFO approach had implication, should enhance the computer-based information system of disposable substance for controlling the practicum substance in Dental faculty of Jember University [O] . Hadnyanawati Hestieyonini 2005

机译：詹伯大学牙科学院的一次性物质库存管理仍然在每个管理级别受到任何限制。这是由于ABC分析方法无法控制一次性物质引起的。尚无从诊所返回的一次性药物可用性的记录方法，无法在任何时间显示库存数据，还没有按位置和物质特性安排恢复，既不适用FEFO（先到先得）， FIFO（先进先出）。通过ABC分析，FEFO和FIFO方法具有一定的意义，应在Jember大学牙科系中增强基于计算机的一次性物质信息系统以控制实习药物
8. Results from a Prenatal Oral Developmental Toxicity Study in Rats with Nitrogen containing Heterocycle, Substituted (Substance A) (Star 2), Nitrogen containing Heterocycle, Substituted (Substance B) (Star 2), Nitrogen containing Heterocycle, Substituted (Substance C) (Star 2), Nitrogen containing Heterocycle, Substituted (Substance D) (Star 2) Nitrogen containing Heterocycle, Substituted (Substance E) (Star 2). [R] . 2009

机译：含氮杂环，取代（物质a）（星2），含氮杂环，取代（物质B）（星2），含氮杂环，取代（物质C）（星）的大鼠的产前口腔发育毒性研究结果2），含氮杂环，取代（物质D）（星形2）含氮杂环，取代（物质E）（星形2）。

Substance P equals pain substance?

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