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首页> 外文期刊>Nature >Paired-spike interactions and synaptic efficacy of retinal inputs to the thalamus.
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Paired-spike interactions and synaptic efficacy of retinal inputs to the thalamus.

机译：视网膜输入丘脑的成对突触相互作用和突触功效。

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In many neural systems studied in vitro, the timing of afferent impulses affects the strength of postsynaptic potentials. The influence of afferent timing on postsynaptic firing in vivo has received less attention. Here we study the importance of afferent spike timing in vivo by recording simultaneously from ganglion cells in the retina and their targets in the lateral geniculate nucleus of the thalamus. When two spikes from a single ganglion-cell axon arrive within 30 milliseconds of each other, the second spike is much more likely than the first to produce a geniculate spike, an effect we call paired-spike enhancement. Furthermore, simultaneous recordings from a ganglion cell and two thalamic targets indicate that paired-spike enhancement increases the frequency of synchronous thalamic activity. We propose that information encoded in the high firing rate of an individual retinal ganglion cell becomes distributed among several geniculate neurons that fire synchronously. Because synchronous geniculate action potentials are highly effective in driving cortical neurons, it is likely that information encoded by this strategy is transmitted to the next level of processing.
机译：在许多体外研究的神经系统中，传入冲动的时间会影响突触后电位的强度。传入时机对体内突触后放电的影响已受到较少的关注。在这里，我们通过同时记录视网膜神经节细胞及其在丘脑外侧膝状核中的靶标，来研究传入突触时机在体内的重要性。当来自单个神经节细胞轴突的两个尖峰彼此之间在30毫秒之内到达时，第二个尖峰比第一个尖峰产生膝状尖峰的可能性要大得多，这种现象称为成对尖峰增强。此外，来自神经节细胞和两个丘脑靶的同时记录表明，成对的尖峰增强增加了同步丘脑活动的频率。我们建议在单个视网膜神经节细胞的高放电率中编码的信息变得分布在同步触发的几个膝状神经元中。由于同步膝状动作电位在驱动皮层神经元方面非常有效，因此该策略编码的信息可能会传输到下一级处理。

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