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首页> 外文期刊>Nature >A function for lipoxygenase in programmed organelle degradation.
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A function for lipoxygenase in programmed organelle degradation.

机译：脂氧合酶在程序化细胞器降解中的功能。

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Membrane-enclosed organelles, a defining characteristic of eukaryotic cells, are lost during differentiation of specific cell types such as reticulocytes (an intermediate in differentiation of erythrocytes), central fibre cells of the eye lens, and keratinocytes. The degradation of these organelles must be tightly regulated with respect to both the time of activation and the specificity of membrane degradation. The expression of 15-lipoxygenase (15-LOX) peaks in reticulocytes immediately before organelle degradation. Here we show that 15-LOX integrates into the membranes of various organelles, allowing release of proteins from the organelle lumen and access of proteases to both lumenal and integral membrane proteins. In addition, by sparing the plasma membrane, 15-LOX shows the required specificity for organellar membranes. Thus, the action of 15-LOX provides a mechanism by which the natural degradation process can be explained. This conclusion is supported by our finding that lipoxygenase expression in the eye lens is restricted to the region at which organelle degradation occurs.
机译：膜包裹的细胞器是真核细胞的定义特征，在特定细胞类型的分化过程中会丢失，例如网状细胞（红细胞分化的中间产物），眼晶状体的中央纤维细胞和角质形成细胞。这些细胞器的降解必须在激活时间和膜降解的特异性方面受到严格控制。在细胞器降解之前，网织红细胞中15-脂氧合酶（15-LOX）的表达达到峰值。在这里，我们显示15-LOX整合到各种细胞器的膜中，从而允许从细胞器内腔释放蛋白质，并使蛋白酶接近内腔和整合膜蛋白。另外，通过保留质膜，15-LOX显示出对细胞器质膜所需的特异性。因此，15-LOX的作用提供了可以解释自然降解过程的机制。我们的发现支持了这一结论，即在眼晶状体中脂氧合酶的表达仅限于发生细胞器降解的区域。

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