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首页> 外文期刊>Nature >Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a.
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Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a.

机译：哺乳动物生殖道的性二形发育需要Wnt-7a。

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摘要

An important feature of mammalian development is the generation of sexually dimorphic reproductive tracts from the Mullerian and Wolffian ducts. In females, Mullerian ducts develop into the oviduct, uterus, cervix and upper vagina, whereas Wolffian ducts regress. In males, testosterone promotes differentiation of Wolffian ducts into the epididymis, vas deferens and seminal vesicle. The Sertoli cells of the testes produce Mullerian-inhibiting substance, which stimulates Mullerian duct regression in males. The receptor for Mullerian-inhibiting substance is expressed by mesenchymal cells underlying the Mullerian duct that are thought to mediate regression of the duct. Mutations that inactivate either Mullerian-inhibiting substance or its receptor allow development of the female reproductive tract in males. These pseudohermaphrodites are frequently infertile because sperm passage is blocked by the presence of the female reproductive system. Here we show that male mice lacking the signalling molecule Wnt-7a fail to undergo regression of the Mullerian duct as a result of the absence of the receptor for Mullerian-inhibiting substance. Wnt7a-deficient females are infertile because of abnormal development of the oviduct and uterus, both of which are Mullerian duct derivatives. Therefore, we propose that signalling by Wnt-7a allows sexually dimorphic development of the Mullerian ducts.
机译：哺乳动物发育的一个重要特征是从穆勒管和沃尔夫管产生性二态生殖道。在女性中，穆勒氏管会发展成输卵管，子宫，子宫颈和上阴道，而沃尔夫氏管会退化。在男性中，睾丸激素可促进Wolffian导管分化为附睾，输精管和精囊。睾丸的支持细胞会产生苗勒氏抑制物质，从而刺激雄性苗勒氏管退化。穆勒抑制物质的受体由穆勒导管下面的间充质细胞表达，认为它们介导了导管的退化。使穆勒抑制物质或其受体失活的突变可使雄性雌性生殖道发育。这些伪雌雄同体通常是不育的，因为雌性生殖系统的存在会阻止精子通过。在这里，我们显示缺少信号分子Wnt-7a的雄性小鼠由于不存在缪勒抑制物质的受体而无法经历穆勒管道的消退。缺乏Wnt7a的女性由于输卵管和子宫的异常发育而无法生育，这两者都是苗勒氏管衍生物。因此，我们建议通过Wnt-7a的信号转导允许穆勒管的性二形发育。

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