Leptin and the regulation of body weight in mammals.

FriedmanJM; HalaasJL

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Leptin and the regulation of body weight in mammals.

机译：瘦素和哺乳动物体重的调节。

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摘要

The assimilation, storage and use of energy from nutrients constitute a homeostatic system that is essential for life. In vertebrates, the ability to store sufficient quantities of energy-dense triglyceride in adipose tissue allows survival during the frequent periods of food deprivation encountered during evolution. However, the presence of excess adipose tissue can be maladaptive. A complex physiological system has evolved to regulate fuel stores and energy balance at an optimum level. Leptin, a hormone secreted by adipose tissue, and its receptor are integral components of this system. Leptin also signals nutritional status to several other physiological systems and modulates their function. Here we review the role of leptin in the control of body weight and its relevance to the pathogenesis of obesity.

机译：来自营养素的能量的吸收，存储和使用构成了生命必不可少的体内平衡系统。在脊椎动物中，在脂肪组织中存储足够数量的能量密集型甘油三酸酯的能力使动物在进化过程中经常遇到的食物匮乏时期得以生存。但是，过量脂肪组织的存在可能会导致适应不良。复杂的生理系统已经发展到可以将燃料存储和能量平衡调节到最佳水平。瘦素（一种由脂肪组织分泌的激素）及其受体是该系统不可或缺的组成部分。瘦素还向其他几个生理系统发出营养状况信号，并调节其功能。在这里，我们审查瘦素在控制体重中的作用及其与肥胖症发病机制的相关性。

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来源
《Nature》 |1998年第6704期|P.763-770|共8页
作者
FriedmanJM; HalaasJL;
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作者单位

Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA. friedj;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Body Weight; Proteins; leptin receptor; Carrier Proteins; Leptin; 体重; 蛋白质类;

机译：Body Weight;Proteins;leptin receptor;Carrier Proteins;Leptin;体重;蛋白质类;

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1. Leptin and body weight regulation in patients with anorexia nervosa before and during weight recovery. [J] . Haas V, Onur S, Paul T, The American Journal of Clinical Nutrition: Official Journal of the American Society for Clinical Nutrition . 2005,第4期

机译：神经性厌食症患者体重恢复之前和期间的瘦素和体重调节。
2. Regulation of body weight by leptin, with special reference to hypoxia-induced regulation. [J] . Yingzhong Y, Droma Y, Rili G, Internal medicine. . 2006,第16期

机译：瘦素对体重的调节，特别是缺氧引起的调节。
3. Regulation of Body Weight by Leptin, with Special Reference to Hypoxia-induced Regulation [J] . Yang Yingzhong, Yunden Droma, Ge Rili, Internal medicine. . 2006,第16期

机译：瘦素对体重的调节，特别是缺氧引起的调节
4. Effect of New Leptin Fragments on Food Intake and Body Weight of Rats [C] . Marta N.C. Martins, Jadson M. Pereira, Monica M. Telles American Peptide Symposium . 2009

机译：新瘦素片段对大鼠食物摄入和体重的影响
5. Effects of recombinant adeno-associated virus encoding leptin on body weight regulation and energy homeostasis. [D] . Dhillon, Harveen. 2000

机译：编码瘦素的重组腺相关病毒对体重调节和能量稳态的影响。
6. The role of established East Asian obesity-related loci on pediatric leptin levels highlights a neuronal influence on body weight regulation in Chinese children and adolescents: the BCAMS study [O] . Junling Fu, Ge Li, Lujiao Li, 2017

机译：BCAMS研究表明已建立的东亚肥胖相关基因座对儿童瘦素水平的作用突出了神经元对中国儿童和青少年体重调节的影响。
7. Molecular Mechanisms of Body Weight Homeostasis and Obesity: Regulation of Food Intake by Leptin and Leptin Resistance [O] . Takafumi SHINTANI 2018

机译：体重稳态和肥胖的分子机制：瘦素和瘦素抗性的食物摄入量调节

Leptin and the regulation of body weight in mammals.

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