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首页> 外文期刊>Nature >Phosphorylation of RNA-binding protein controls cell cycle switch from mitotic to meiotic in fission yeast
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Phosphorylation of RNA-binding protein controls cell cycle switch from mitotic to meiotic in fission yeast

机译：RNA结合蛋白的磷酸化控制裂变酵母中细胞周期从有丝分裂到减数分裂的转变

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摘要

Meiosis generates haploid gametes from diploid cells and is an almost universal feature of eukaryotic organisms. But little is known about how the switch from mitotic to meiotic cell cycles is molecularly controlled. In the fission yeast Schizosaccharomyces pombe, inactivation of the protein kinase Pat1(Ran1) upon nutrient deprivation triggers entry into the meiotic cell cycle. Here we show that the RNA-binding protein Mei2 is a substrate of Pat1 kinase and that dephosphorylation of Mei2 is sufficient to switch cells from the mitotic cell cycle into meiosis. Mei2 is localized mainly in the cytoplasm of proliferating cells but is seen as a single spot close to the microtubule organizing centre in prophase nuclei during meiosis. Our results, and others from a metazoan, emphasize the crucial role of RNA-binding proteins in the initiation and execution of meiosis.
机译：减数分裂从二倍体细胞产生单倍体配子，并且是真核生物的几乎普遍特征。但是，如何从分子有丝分裂控制从有丝分裂到减数分裂的细胞周期知之甚少。在裂殖酵母粟酒裂殖酵母中，蛋白激酶Pat1（Ran1）在营养物质缺乏时失活触发进入减数分裂细胞周期。在这里，我们显示RNA结合蛋白Mei2是Pat1激酶的底物，Mei2的去磷酸化足以将细胞从有丝分裂细胞周期转换为减数分裂。 Mei2主要位于增生细胞的细胞质中，但在减数分裂过程中被视为靠近前核中微管组织中心的单个点。我们的结果以及后生动物的其他结果都强调了RNA结合蛋白在减数分裂的启动和执行中的关键作用。

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