首页> 外文期刊>Nature >Proviruses pose potential problems
【24h】

Proviruses pose potential problems

机译:前病毒构成潜在问题

获取原文
获取原文并翻译 | 示例
           

摘要

Organ transplantation could save — or greatly improve the quality of— the lives of many people. However, there is a shortage of suitable donated human organs, so attention has turned to the possibility of transplanting primate or pig organs. Using transgenic animals designed to minimize the activation of human complement, considerable progress has been made in preventing immunological rejection of transplanted organs. Yet clinical trials have been delayed, mainly due to fears that such procedures might facilitate the introduction of novel viruses, particularly retroviruses, to the human population. This was largely a theoretical risk, at least in the case of pigs, as no such viruses had been described. But a report by Patience and colleagues in the March issue of Nature Medi-cine indicates that there are grounds for prac-tical concern. They provide evidence that at least one pig cell line produces a retrovirus that can infect human cells, and that a related virus is expressed in normal pig tissues.
机译:器官移植可以挽救许多人的生命,或者可以大大改善他们的生活质量。但是,缺少合适的捐赠人体器官,因此人们的注意力转向了移植灵长类或猪器官的可能性。使用设计用于最小化人类补体激活的转基因动物,在预防移植器官的免疫排斥方面取得了相当大的进步。然而,临床试验被推迟了,主要是因为担心这种方法可能会促进向人群中引入新病毒,特别是逆转录病毒。这在很大程度上是理论上的风险,至少对于猪来说,是因为没有描述这种病毒。但是Patience及其同事在三月号的《自然医学》杂志上的一份报告指出,存在着引起实际关注的理由。他们提供了证据,证明至少有一种猪细胞系产生可以感染人类细胞的逆转录病毒,并且在正常的猪组织中表达了相关病毒。

著录项

  • 来源
    《Nature》 |1997年第6621期|p.126-127|共2页
  • 作者

    Jonathan P. Stoye;

  • 作者单位
  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 自然科学总论;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号