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The Rx homeobox gene is essential for vertebrate eye development

机译：Rx同源盒基因对于脊椎动物的眼睛发育至关重要

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摘要

Development of the vertebrate eye requires a series of steps including specification of the anterior neural plate, evagination of the optic vesicles from the ventral forebrain, and the cellular differentiation of the lens and retina. Homeobox-containing genes, especially the transcription regulator Pax6, play a critical role in vertebrate and invertebrate eye formation. Mutations in Pax6 function result in eye malformations known as Aniridia in humans and Small eye syndrome in mice. The Drosophila homologue of Pax6, eyeless, is also necessary for correct invertebrate eye development, and its misexpression leads to formation of ectopic eyes in Drosophila. Here we show that a conserved vertebrate homeobox gene, Rx, is essential for normal eye development, and that its misexpression has profound effects on eye morphology. Xenopus embryos injected with synthetic Rx RNA develop ectopic retinal tissue and display hyperproliferation in the neuroretina. Mouse embryos carrying a null allele of this gene do not form optic cups and so do not develop eyes. The Rx gene family plays an important role in the establishment and/or proliferation of retinal progenitor cells.
机译：脊椎动物眼睛的发育需要一系列步骤，包括指定前神经板，从前脑腹侧视觉小囊的撤离以及晶状体和视网膜的细胞分化。含同源盒的基因，尤其是转录调节因子Pax6，在脊椎动物和无脊椎动物眼的形成中起着关键作用。 Pax6功能的突变会导致人眼畸形（称为人虹膜虹膜）和小鼠小眼综合症。 Pax6的果蝇同源物（无眼）对于正确无脊椎动物的眼睛发育也是必需的，其错误表达会导致果蝇中异位眼的形成。在这里，我们显示保守的脊椎动物同源异型盒基因Rx对于正常的眼睛发育至关重要，并且其错误表达对眼睛的形态具有深远的影响。注射了合成Rx RNA的非洲爪蟾胚胎会发育出异位的视网膜组织，并在神经视网膜中显示过度增殖。携带该基因无效等位基因的小鼠胚胎不会形成视杯，因此不会发育成眼睛。 Rx基因家族在视网膜祖细胞的建立和/或增殖中起重要作用。

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