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首页> 外文期刊>Nature >Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase
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Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase

机译：Neurturin反应性需要GPI连锁受体和Ret受体酪氨酸激酶

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摘要

Neurturin (NTN) is a recently identified homologue of glial-cell-line-derived neurotrophic factor (GDNF). Both factors promote the survival of a variety of neurons, and GDNF is required for the development of the enteric nervous system and kidney. GDNF signals through a receptor complex consisting of the receptor tyrosine kinase Ret and a glycosyl-phosphatidylinositol (GPI)-linked receptor termed GDNFR-alpha. Here we report the cloning of a new GPI-linked receptor termed NTNR-alpha that is homologous with GDNFR-alpha and is widely expressed in the nervous system and other tissues. By using microinjection to introduce expression plasmids into neurons, we show that coexpression of NTNR-alpha with Ret confers a survival response to neurturin but not GDNF, and that coexpression of GDNFR-alpha with Ret confers a survival response to GDNF but not neurturin. Our findings indicate that GDNF and neurturin promote neuronal survival by signalling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.
机译：Neurturin（NTN）是神经胶质细胞系神经营养因子（GDNF）的最近鉴定的同源物。这两个因素都可以促进多种神经元的存活，而肠神经系统和肾脏的发育则需要GDNF。 GDNF通过受体酪氨酸激酶Ret和糖基磷脂酰肌醇（GPI）连接的受体GDNFR-alpha组成的受体复合物发出信号。在这里，我们报道了一种新的GPI连锁受体NTNR-alpha的克隆，该受体与GDNFR-alpha同源，并在神经系统和其他组织中广泛表达。通过使用显微注射将表达质粒引入神经元，我们显示NTNR-α与Ret的共表达赋予了对神经营养素而不是GDNF的存活反应，而GDNFR-α与Ret的共表达赋予了对GDNF但对神经营养素没有存活的反应。我们的发现表明，GDNF和神经营养蛋白通过类似的多组分受体发出信号来促进神经元的存活，该多组分受体由一个共同的酪氨酸激酶和一个GPI连锁的受体家族决定配体特异性。

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