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Placing death under control

机译:将死亡置于控制之下

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摘要

Unlike the gloomy connotation of the death of an organism, the death of an individual ceil is an integral and continuing part of normal physiology. It is also a major form of defence, as sometimes the only way for the immune system to eradicate pathogens is to sacrifice the infected cell. When the timing of ceE death is inappropriate, however, havoc may ensue. So understanding the mechanisms that regulate cell death is just as important as understanding those responsible for the actual killing. A newly identified protein, described on page 190 of this issue by Irmler et al., and in Immunity by Shu et al., appears to act as a regulator of one of the principal ways by which immune mechanisms cause celf death - namely its induction by receptors belonging to the tumour necrosis factor (TNF)-receptoi family. This is a highly ctive research area, as exemplified by the fadf that three other groups, including my own, are shortly to publish on the same protein.
机译:与生物死亡的阴郁含义不同,单个细胞的死亡是正常生理学不可或缺的组成部分。它也是防御的主要形式,因为有时免疫系统根除病原体的唯一方法是牺牲被感染的细胞。但是,当ceE死亡的时间不合适时,可能会造成破坏。因此,了解调节细胞死亡的机制与了解造成实际杀伤的因素一样重要。一种新鉴定的蛋白质,在Irmler等人的本期杂志第190页中描述,在Shu等人的《免疫学》中,它似乎是免疫机制导致细胞死亡的一种主要方式的调节剂-即其诱导属于肿瘤坏死因子(TNF)受体家族的受体这是一个非常活跃的研究领域,例如faff就是一个例子,其他三个小组(包括我的小组)不久将发布同一蛋白质。

著录项

  • 来源
    《Nature》 |1997年第6638期|p.123125-126|共3页
  • 作者

    David Wallaeh;

  • 作者单位
  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 自然科学总论;
  • 关键词

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